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Rimonabant
go.drugbank.com/drugs/DB06155ApprovedWithdrawnThis decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression. … Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States.
Categories: Heterocyclic Compounds, 1-Ring, Cannabinoids and similarsProducts: ACOMPLIA ® COMPRIMIDOS RECUBIERTOS20 MGEliglustat
go.drugbank.com/drugs/DB09039ApprovedInvestigationalEliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease. … [A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide.
Categories: Heterocyclic Compounds, 1-Ring, Alimentary Tract and MetabolismSynonyms: N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamideBesifloxacin
go.drugbank.com/drugs/DB06771ApprovedBesifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.
Categories: Heterocyclic Compounds, 1-Ring, 4-QuinolonesProducts: BESIVANCE % 0,6 OFTALMIK SÜSPANSIYON, 5 MLPotassium bicarbonate
go.drugbank.com/drugs/DB11098ApprovedInvestigationalPotassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. … [T141] It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids.[L1836] This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.
Mixtures: GALVİKS ADVANCE 1000 MG+200 MG/10 ML ORAL SÜSPANSİYON, 200 ML, REFCON ADVANCE 100 MG + 20 MG/ML ORAL SÜSPANSIYONCategories: Alimentary Tract and MetabolismLisdexamfetamine
go.drugbank.com/drugs/DB01255ApprovedInvestigationalLisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine,[A40246] covalently attached to the naturally occurring amino acid L-lysine. … [L48285] Lisdexamfetamine works to treat attention deficit hyperactivity disorder and binge eating disorder [A2230] by blocking dopamine and norepinephrine reuptake and increasing their levels in the extraneuronal
Categories: Psychostimulants, Agents Used for ADHD and NootropicsProducts: VYVANSE® 50 MG CAPSULAS, VYVANSE CAPSULES 50 mgPolyunsaturated fatty acid 5-lipoxygenase
go.drugbank.com/bio_entities/BE0000248TargetEnzymeHumansCatalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4
Polypeptides: Polyunsaturated fatty acid 5-lipoxygenaseSynonyms: 5-LO, 5-lipoxygenaseS-methyl-5'-thioadenosine phosphorylase
go.drugbank.com/bio_entities/BE0001128TargetHumansCatalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate (PubMed:3091600, PubMed:8687427, PubMed:10404592).
Polypeptides: S-methyl-5'-thioadenosine phosphorylaseSynonyms: 5'-methylthioadenosine phosphorylaseRibose-5-phosphate isomerase A
go.drugbank.com/bio_entities/BE0001557TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Polypeptides: Ribose-5-phosphate isomerase AFunction: ribose-5-phosphate isomerase activityProtein-glutamine gamma-glutamyltransferase 5
go.drugbank.com/bio_entities/BE0002236EnzymeHumansCatalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes
Polypeptides: Protein-glutamine gamma-glutamyltransferase 5Synonyms: TGase-5, Transglutaminase-5Excitatory amino acid transporter 5
go.drugbank.com/bio_entities/BE0002267TargetHumansSodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions a...
Polypeptides: Excitatory amino acid transporter 5