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Cytochrome b-c1 complex subunit 10
go.drugbank.com/bio_entities/BE0003859TargetHumansComponent of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit...
Polypeptides: Cytochrome b-c1 complex subunit 10Synonyms: Complex III subunit 10Efalizumab
go.drugbank.com/drugs/DB00095ApprovedWithdrawnEfalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. … It was later withdrawn in 2009 due to a potential risk of progressive multifocal leukoencephalopathy (PML).[L43797]
Products: RAPTIVA ®125 MGPenbutolol
go.drugbank.com/drugs/DB01359ApprovedInvestigationalWithdrawnPenbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. … Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT1A Receptor AntagonistsSynonyms: (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-olBrentuximab vedotin
go.drugbank.com/drugs/DB08870ApprovedInvestigational[L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy regimen compared to the previous standard of care. … Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE).
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: Monoclonal antibody SGN-30, Moab, chimeric, SGN-30, to CD30 antigenDolichovespula arenaria venom protein
go.drugbank.com/drugs/DB10957ApprovedDolichovespula arenaria venom protein is an extract of Dolichovespula arenaria venom. Dolichovespula arenaria venom protein is used in allergenic testing.
Mixtures: Mixed Vespid Venom Protein Multidose 13.0 Ml (3900 Mcg), Hymenoptera Venom Product-mixed Vespid Venom Protein (1650 Mcg)Products: Venomil Inj 10mcg/ml Yellow Hornet, Venomil Inj 100mcg/ml(yellow Hornet)Rilmenidine
go.drugbank.com/drugs/DB11738ApprovedWithdrawnRilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor AgonistsProducts: HYPERIUM 1 MG TABLET, 30 ADET, Iterium 1 mg - TablettenDeucravacitinib
go.drugbank.com/drugs/DB16650ApprovedInvestigationalUnlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity … Deucravacitinib is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor.
Categories: Tyrosine Kinase 2 Inhibitor, P-glycoprotein substratesProducts: SOTYKTU 6 mg film coated tablets, SOTYKTU® 6MG TABLETAS RECUBIERTASPentamidine
go.drugbank.com/drugs/DB00738ApprovedInvestigationalIt may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: p,p'-(pentamethylenedioxy)dibenzamidine, 1,5-bis(4-amidinophenoxy)pentanePropantheline
go.drugbank.com/drugs/DB00782ApprovedA muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Categories: Heterocyclic Compounds, 3-RingProducts: Pro-banthine Tablets 7.5 mgDL-alpha tocopheryl acetate
go.drugbank.com/drugs/DB14477ApprovedMixtures: Folika-MG, PNV Tabs 29-1Categories: Vitamin E