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Displaying results 3671 - 3680 of 10000 in total
  1. Drug

    Grepafloxacin

    go.drugbank.com/drugs/DB00365
    ApprovedWithdrawn

    Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States … Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections.

  2. Drug

    Sarracenia Purpurea

    go.drugbank.com/drugs/DB13965
    ApprovedWithdrawn

    Cytoprotection in an in vitro model of diabetic neuropathy has also been studied. However, the use of Sarracenia Purpurea extracts in the clinical setting are limited. … It is widely distributed across North America and has been used as a traditional medicinal herb in many aboriginal communities [A32509, A32510].

  3. Drug

    Resveratrol

    go.drugbank.com/drugs/DB02709
    Investigational

    It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as cis-(Z) and trans-(E) isomers. … In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: (E)-resveratrol, (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
  4. Drug

    Rotenone

    go.drugbank.com/drugs/DB11457
    ExperimentalVet approved

    Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.

    Categories: Compounds used in a research, industrial, or household setting
  5. Drug

    Eliprodil

    go.drugbank.com/drugs/DB12869
    Investigational

    Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    Linsitinib

    go.drugbank.com/drugs/DB06075
    Investigational

    IGF-1R inhibitor OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. … An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity.

  7. Drug

    GI-4000

    go.drugbank.com/drugs/DB05698
    Investigational

    A vaccine containing a heat-killed recombinant <em>Saccharomyces cerevisiae</em> yeast transfected with mutated forms of Ras, an oncogene frequently found in solid tumors, with potential immunostimulant

  8. Drug

    Varespladib methyl

    go.drugbank.com/drugs/DB05737
    Investigational

    Studies showed that Varespladib methyl treatment resulted in significant positive changes on lipoproteins and inflammation.

  9. Drug

    Indirubin

    go.drugbank.com/drugs/DB12379
    Investigational

    Indirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment).

    Categories: Compounds used in a research, industrial, or household setting
  10. Target

    NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

    go.drugbank.com/bio_entities/BE0000027
    TargetHumans

    May be the terminally assembled subunit of Complex I … Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.

    Synonyms: Complex I-9kD