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Displaying results 3681 - 3690 of 10000 in total
  1. Target

    Histone deacetylase 5

    go.drugbank.com/bio_entities/BE0009578
    TargetHumans

    In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional reg...

    Polypeptides: Histone deacetylase 5
  2. Target

    Melanocortin receptor 5

    go.drugbank.com/bio_entities/BE0009684
    TargetHumans

    G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929). Upon activation, couples to G(s) prot...

    Polypeptides: Melanocortin receptor 5
  3. Target

    Pepsin A-5

    go.drugbank.com/bio_entities/BE0009737
    TargetHumans

    Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent

    Polypeptides: Pepsin A-5Synonyms: Pepsinogen-5
  4. Target

    Integrin beta-5

    go.drugbank.com/bio_entities/BE0012746
    TargetHumans

    Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand

    Polypeptides: Integrin beta-5
  5. Drug

    Norethindrone enanthate

    go.drugbank.com/drugs/DB14678
    Investigational

    Mixtures: MESIGYNA 5 MG+50 MG/1 ML ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR ENJEKTÖR, MESIGYNA®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Methyl salicylate

    go.drugbank.com/drugs/DB09543
    ApprovedInvestigationalVet approved

    It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments. … It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen.

    Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, SADRÜD % 10 + % 15 JEL, 50 GCategories: Compounds used in a research, industrial, or household setting
  7. Drug

    Carisoprodol

    go.drugbank.com/drugs/DB00395
    Approved

    for abuse in addition to a low risk of dependence [L5074]. … In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesSynonyms: (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester, N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate
  8. Drug

    Icosapent ethyl

    go.drugbank.com/drugs/DB08887
    ApprovedInvestigationalNutraceutical

    It is used as an adjunct therapy for severe hypertriglyceridemia (TG levels > 500 mg/dL) and to reduce the risk of cardiovascular events in certain patients with elevated triglycerides. … FDA approved on July 26, 2012.

    Categories: Fatty Acids, Omega-3Synonyms: E-EPA, ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate
  9. Drug

    Zinc citrate

    go.drugbank.com/drugs/DB11154
    ApprovedInvestigational

    Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element.

    Mixtures: Cal-mag Complete With Zinc, C and D, Corvite 150Products: Zinc 50 mg
  10. Drug

    Elosulfase alfa

    go.drugbank.com/drugs/DB09051
    ApprovedInvestigational

    The recommended dose is 2 mg per kg given intravenously over a minimum range of 3.5 to 4.5 hours, based on infusion volume, once every week. … Elosulfase alfa is a synthetic version of the enzyme N-acetylgalactosamine-6-sulfatase. It was approved by the FDA in 2014 for the treatment of Morquio syndrome.

    Synonyms: Recombinant human N-acetylgalactosamine-6-sulfatase, Recombinant human N-acetylgalactosamine-6-sulfatase (rhGALNS)Products: VIMIZIM® 1MG/ML SOLUCIÓN CONCENTRADA PARA INFUSIÓN, Vimizim 1mg/ml Concentrate for Solution for Infusion