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Displaying results 361 - 370 of 3387 in total
  1. Target

    Poliovirus receptor

    go.drugbank.com/bio_entities/BE0004247
    TargetHumans

    Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological sy...

    Polypeptides: Poliovirus receptor
  2. Target

    NMDA receptor

    go.drugbank.com/bio_entities/BE0004956
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. … Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639).

    Polypeptides: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2ASynonyms: Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1
  3. Target

    Somatostatin receptor

    go.drugbank.com/bio_entities/BE0010008
    TargetHumans

  4. Target

    Fibronectin receptor

    go.drugbank.com/bio_entities/BE0010279
    TargetHumans

    Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. … ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).

    Synonyms: Fibronectin receptor subunit alpha, Fibronectin receptor subunit beta
  5. Target

    Adiponectin receptor

    go.drugbank.com/bio_entities/BE0010287
    TargetHumans

    Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.

    Polypeptides: Adiponectin receptor protein 1, Adiponectin receptor protein 2Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I
  6. Drug

    Omega-3 fatty acids

    go.drugbank.com/drugs/DB11133
    ApprovedInvestigationalNutraceutical

    Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) with a double bond at the third carbon atom from the end of the carbon chain. The three types of omega-3 fatty acids involved in human physiology are α-linolenic acid (ALA) (fou...

    Mixtures: Se-Tan DHA, Se-Tan DHA
  7. Drug

    Mitapivat

    go.drugbank.com/drugs/DB16236
    ApprovedInvestigational

    [A245478] On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  8. Drug

    Aluminum zirconium octachlorohydrex gly

    go.drugbank.com/drugs/DB11200
    Approved

    Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent , . It diffuses into the sweat pores and prevents perspiration (sweat) from leavin...

    Products: Secret Outlast pH Balanced Invisible, Lady Speed Stick Clinical Proof pH active
  9. Drug

    Ethanol

    go.drugbank.com/drugs/DB00898
    ApprovedInvestigational

    A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in ...

    Categories: NMDA Receptor Antagonists, Cytochrome P-450 SubstratesProducts: Anti-Bacterial Hand Sun Tan Summer, P P International Inc. Hand Sanitizer
  10. Drug

    Encainide

    go.drugbank.com/drugs/DB01228
    ApprovedWithdrawn

    Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: (±)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide