| DB00333 | Methadone | approved | yes | antagonist | Details |
| DB04896 | Milnacipran | approved, investigational | unknown | inhibitor | Details |
| DB00289 | Atomoxetine | approved | unknown | blocker | Details |
| DB00312 | Pentobarbital | approved, investigational, vet_approved | unknown | antagonist | Details |
| DB00418 | Secobarbital | approved, vet_approved | unknown | antagonist | Details |
| DB01174 | Phenobarbital | approved, investigational | unknown | antagonist | Details |
| DB01708 | Prasterone | approved, investigational, nutraceutical | unknown | agonist | Details |
| DB06738 | Ketobemidone | investigational | unknown | antagonist | Details |
| DB11823 | Esketamine | approved, investigational | unknown | antagonist | Details |
| DB00874 | Guaifenesin | approved, investigational, vet_approved | unknown | antagonist | Details |
| DB00843 | Donepezil | approved | unknown | downregulator | Details |
| DB00193 | Tramadol | approved, investigational | yes | inhibitor | Details |
| DB00647 | Dextropropoxyphene | approved, illicit, investigational, withdrawn | unknown | antagonist | Details |