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TAK-448
go.drugbank.com/drugs/DB11975InvestigationalTAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
Exatecan
go.drugbank.com/drugs/DB12185InvestigationalExatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.
Categories: Topoisomerase I InhibitorsEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalEsomeprazole has been shown to inhibit acid secretion to a similar extent as [DB00338], without any significant differences between the two compounds _in vitro_. … Esomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer.
Synonyms: (S)-omeprazole, (S)-(−)-omeprazoleMixtures: RUMONAL® PRO 15, RUMONAL® PRO 7.5SAR445136
go.drugbank.com/drugs/DB17708InvestigationalSAR445136 is an investigational zinc finger nuclease gene-edited cell therapy. … It consists of autologous CD34+ hematopoietic stem precursor cells (HSPC) modified ex vivo by zinc finger nucleases (ZFN) that target the BCL11A gene erythroid-specific enhancer (ESE) to increase endogenous
Collectin-12
go.drugbank.com/bio_entities/BE0015432TargetHumansScavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast.
Synonyms: Nurse cell scavenger receptor 2, Scavenger receptor class A member 4Mangafodipir
go.drugbank.com/drugs/DB06796ApprovedInvestigationalWithdrawnMangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas. … Teslascan has been removed from the Drug Product List by FDA in 2003, and withdrawn from the European market in 2012.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingProducts: TESLASCAN 0,01MMOL 50 ML FLAKON, 1 ADETTriamcinolone
go.drugbank.com/drugs/DB00620ApprovedInvestigationalVet approved[L8249] Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate. … [L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L8264] or first line as a topical treatment of corticosteroid responsive dermatoses.
Synonyms: 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneInternational brands: Omcilon-AL-lactate dehydrogenase A chain
go.drugbank.com/bio_entities/BE0000425TargetHumansInterconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)
Synonyms: Cell proliferation-inducing gene 19 proteinTranscription factor p65
go.drugbank.com/bio_entities/BE0005551TargetHumansBesides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. … Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression.
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Ubiquitin-conjugating enzyme E2 T
go.drugbank.com/bio_entities/BE0019778TargetHumansAccepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fan...
Synonyms: Cell proliferation-inducing gene 50 protein