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Displaying results 3731 - 3740 of 10000 in total
  1. Drug

    Valbenazine

    go.drugbank.com/drugs/DB11915
    ApprovedInvestigational

    The reduction in chorea severity was observed as early as 2 weeks after starting treatment with an initial dose of 40 mg.[L47910] … Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: REMLEAS HARD CAPSULES 40 MG, REMLEAS™ hard capsules 40mg
  2. Drug

    Dirithromycin

    go.drugbank.com/drugs/DB00954
    Investigational

    Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: (9S)-9-deoxo-11-deoxy-9,11-(imino((1R)-2-(2-methoxyethoxy)ethylidene)oxy)erythromycin
  3. Drug

    Mifepristone

    go.drugbank.com/drugs/DB00834
    ApprovedInvestigational

    The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials). … Mifepristone is a progestational and glucocorticoid hormone antagonist.

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MG
  4. Drug

    Rilmenidine

    go.drugbank.com/drugs/DB11738
    ApprovedWithdrawn

    Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.

    Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor AgonistsProducts: Iterium 1 mg - Tabletten, HYPERIUM 1 MG TABLET, 30 ADET
  5. Drug

    Selpercatinib

    go.drugbank.com/drugs/DB15685
    ApprovedInvestigational

    Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. … [A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers.

    Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
  6. Drug

    Raltitrexed

    go.drugbank.com/drugs/DB00293
    ApprovedInvestigational

    Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingProducts: TOMUDEX 2 MG FLAKON, 1 ADET, TOMUDEX ® 2 MG
  7. Drug

    Ethionamide

    go.drugbank.com/drugs/DB00609
    ApprovedInvestigationalWithdrawn

    A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)

    Categories: Heterocyclic Compounds, 1-RingSynonyms: ETH, ETP
  8. Pathway

    Cardiolipin Biosynthesis CL(10:0/10:0/10:0/18:2(9Z,11Z))

    smpdb.ca/view/SMP0175283
    Metabolic

    Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial...

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
  9. Drug

    Baloxavir marboxil

    go.drugbank.com/drugs/DB13997
    ApprovedInvestigational

    [L4779] It was also approved by the European Commission on January 7, 2021.[L45241] … More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: XOFLUZA 40 MG FİLM KAPLI TABLET, 1 ADET, XOFLUZA 20 MG FİLM KAPLI TABLET, 2 ADET
  10. Drug

    D-alpha-Tocopherol acetate

    go.drugbank.com/drugs/DB14002
    ApprovedNutraceuticalVet approved

    The recommended dietary allowances (RDAs) for vitamin E alpha-tocopherol are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months … = 15 mg (22.4 IU) females = 15 mg (22.4 IU) pregnancy = 15 mg (22.4 IU) lactation = 19 mg (28.4 IU) in ages 14+ years [L2120].

    Synonyms: Vitamin E acetate, D-, D-alpha tocoferil acetateMixtures: Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn, IQQU Advanced Sunscreen SPF 50