Dirithromycin is an antibiotic used to treat a variety of respiratory, skin, and other infections.
- Mechanism
- Curator reviewed
Dirithromycin prevents bacteria from growing, by interfering with their protein synthesis. Dirithromycin binds to the 50S subunit of the 70S bacterial ribosome, and thus inhibits the translocation of peptides. Dirithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, dirithromycin binds simultaneously in to two domains of 23S RNA of the ribosomal subunit 50S, where older macrolides bind only in one. Dirithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.
- Primary indication
- For the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and uncomplicated skin and skin structure...Curator reviewed · 15 structured indications
- Formula / weight
- C42H78N2O14 · 835.086 g/mol (avg)
- Code names
- LY-237216
Resolves to
WLOHNSSYAXHWNR-DWIOZXRMSA-NSMILESCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)[C@@H]2N[C@@H](COCCOC)O[C@H]([C@H]2C)[C@]1(C)OWhat you can answer from here — as of September 23, 2026
Which other approved drugs treat the same conditions as Dirithromycin, and which companies have late-stage candidates in those indications?
Create a free account or log in to explore the full data card.
Create Account