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Afatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalAfatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. … For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: GIOTRIF® 50 MG, GIOTRIF® 30 MGTeriparatide
go.drugbank.com/drugs/DB06285ApprovedInvestigationalTeriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent.[A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. … [A251395] First approved in the United States in November 2002 and in Europe in April 2003,[A251400] teriparatide makes the first approved drug in a new category of osteoporosis therapy called anabolic
Synonyms: PTH 1-34, PTH (1-34)Products: FORTEO® 250MCG/ML, MEGAPTH-G Teriparatide 20 micrograms / 80 microliters solution for injectionArformoterol
go.drugbank.com/drugs/DB01274ApprovedArformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.
Synonyms: (R,R)-formoterolMixtures: AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 120 KPS, AIRBIR 3/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 60 KPSRamosetron
go.drugbank.com/drugs/DB09290InvestigationalIt is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. … Ramosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: IRRIBOW TABLET 5 MCG, NASEA(R) TABLET 0.1 MGSaquinavir
go.drugbank.com/drugs/DB01232ApprovedInvestigationalSaquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. … In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a relatively benign adverse effect profile as compared
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: SAQUINAVIR 500 MG TABLETAS., SAQUINAVIR 500 MG TABLETA RECUBIERTASodium channel protein type 5 subunit alpha
go.drugbank.com/bio_entities/BE0000197TargetHumansPore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...
Polypeptides: Sodium channel protein type 5 subunit alphaTumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
Polypeptides: Tumor necrosis factor receptor superfamily member 5cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
go.drugbank.com/bio_entities/BE0001223TargetHumansCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibitin...
Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BFunction: 3',5'-cyclic-AMP phosphodiesterase activityIntracellular exo-alpha-(1->5)-L-arabinofuranosidase
go.drugbank.com/bio_entities/BE0001766TargetGeobacillus stearothermophilusCatalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (branched and debranched arabinans).
Polypeptides: Intracellular exo-alpha-(1->5)-L-arabinofuranosidaseSynonyms: Intracellular arabinan exo-alpha-(1->5)-L-arabinosidaseNAD-dependent protein deacylase sirtuin-5, mitochondrial
go.drugbank.com/bio_entities/BE0003362TargetHumansNAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 an...
Polypeptides: NAD-dependent protein deacylase sirtuin-5, mitochondrialSynonyms: SIR2-like protein 5, Regulatory protein SIR2 homolog 5