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Displaying results 3751 - 3760 of 10000 in total
  1. Target

    T-cell surface glycoprotein CD3 delta chain

    go.drugbank.com/bio_entities/BE0003456
    TargetHumans

    When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.

    Synonyms: T-cell receptor T3 delta chain
  2. Target

    T-cell surface glycoprotein CD3 gamma chain

    go.drugbank.com/bio_entities/BE0003457
    TargetHumans

    Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G … When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.

    Synonyms: T-cell receptor T3 gamma chain
  3. Target

    P2Y purinoceptor 4

    go.drugbank.com/bio_entities/BE0009822
    TargetHumans

    Receptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

    Synonyms: Uridine nucleotide receptorFunction: G protein-coupled purinergic nucleotide receptor activity
  4. Drug

    Siplizumab

    go.drugbank.com/drugs/DB06371
    Investigational

  5. Drug

    Denibulin

    go.drugbank.com/drugs/DB05932
    Experimental

    Denibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.

    Categories: Heterocyclic Compounds, 2-Ring
  6. Drug

    VPM1002

    go.drugbank.com/drugs/DB15801
    Investigational

    This vaccine’s urease C gene is replaced with the listeriolysin O encoding gene from Listeria monocytogenes. … Currently, this recombinant vaccine has been found to be more efficacious and safer than BCG in preclinical studies.

  7. Drug

    Deanol

    go.drugbank.com/drugs/DB13352
    Investigational

    Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. … It has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.

    Synonyms: 2-(dimethylamino)ethanol
  8. Drug

    Psilocybin

    go.drugbank.com/drugs/DB11664
    Investigational

    Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA.

    Categories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Aceneuramic acid

    go.drugbank.com/drugs/DB11797
    Investigational

    Aceneuramic acid has been used in trials studying the treatment of Distal Myopathy, Nonaka Type, Hereditary Inclusion Body Myopathy, and Distal Myopathy With Rimmed Vacuoles.

  10. Drug

    PZ-128

    go.drugbank.com/drugs/DB11839
    Investigational

    PZ-128 has been used in trials studying the prevention and treatment of Heart Diseases, Coronary Disease, Arteriosclerosis, Vascular Diseases, and Myocardial Ischemia, among others.