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Displaying results 3751 - 3760 of 7502 in total
  1. Drug

    Mirfentanil

    go.drugbank.com/drugs/DB09175
    Experimental

    At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action. … lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to

  2. Drug

    WP-1301

    go.drugbank.com/drugs/DB17702
    Experimental

    It binds to an MHC class II molecule and is recognized by a Factor VIII-specific T cell.[L46138]

  3. Drug

    XT-150

    go.drugbank.com/drugs/DB21756
    Investigational

    XT-150 is a locally injectable non-viral therapy expressing IL-10v, a proprietary modified variant of IL-10.[L52125] It is being developed by Xalud Therapeutics.

    Synonyms: non-viral human interleukin-10 (IL-10) variant (IL-10var) encoding plasmid deoxyribonucleic acid (pDNA)
  4. Drug

    Azelastine

    go.drugbank.com/drugs/DB00972
    ApprovedInvestigational

    [L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first granted FDA approval in 1996.

    Mixtures: N-S-4Categories: Histamine H1 Antagonists, Non-Sedating
  5. Drug

    Vicriviroc

    go.drugbank.com/drugs/DB06652
    Investigational

    This drug was developed by Schering-Plough.

  6. Drug

    Medrysone

    go.drugbank.com/drugs/DB00253
    Approved

    Medrysone is a corticosteroid used in ophthalmology.

  7. Drug

    Pine needle oil (pinus mugo)

    go.drugbank.com/drugs/DB11276
    Approved

    Pine needle oil is obtained from the needles of Pinus mugo tree via steam distillation. Major components of pine needle oil (pinus mugo) include α-Pinene, β-pinene, δ-3-carene, limonene, β-phellandrene, (E)-caryophyllene, and germacrene ...

    Mixtures: Co Cool
  8. Drug

    5-androstenedione

    go.drugbank.com/drugs/DB01456
    ExperimentalIllicit

    Apart from the positioning of a carbon-carbon double bond, its structure is similar to [4-androstenedione], which is a prohormone which is naturally produced in the body by the adrenal glands and gonads … Thus 5-androstenedione is a controlled substance, and its use in athletes is prohibited by The World Anti-Doping Agency.

  9. Drug

    IL15-NK Cell

    go.drugbank.com/drugs/DB15725
    Investigational

    In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to. … Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity.

    Synonyms: IL15-NK Cell
  10. Drug

    Aldosterone

    go.drugbank.com/drugs/DB04630
    Investigational

    A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.