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Displaying results 3761 - 3770 of 10000 in total
  1. Drug

    Dirithromycin

    go.drugbank.com/drugs/DB00954
    Investigational

    Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: (9S)-9-deoxo-11-deoxy-9,11-(imino((1R)-2-(2-methoxyethoxy)ethylidene)oxy)erythromycin
  2. Drug

    Mifepristone

    go.drugbank.com/drugs/DB00834
    ApprovedInvestigational

    The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials). … Mifepristone is a progestational and glucocorticoid hormone antagonist.

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MG
  3. Drug

    Dactylis glomerata pollen

    go.drugbank.com/drugs/DB10379
    Approved

    Dactylis glomerata pollen is the pollen of the Dactylis glomerata plant. Dactylis glomerata pollen is mainly used in allergenic testing.

    Mixtures: Oralair 100 IR, ORALAIR 100 IR + 300 IR SublingualtablettenProducts: Standardized Grass Pollen - Orchard Grass (100 Bau/ml), Standardized Grass Pollen - Orchard Grass (100000 Bau/ml)
  4. Pathway

    Cardiolipin Biosynthesis CL(10:0/10:0/10:0/18:2(9Z,11Z))

    smpdb.ca/view/SMP0175283
    Metabolic

    Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial...

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
  5. Drug

    Baloxavir marboxil

    go.drugbank.com/drugs/DB13997
    ApprovedInvestigational

    [L4779] It was also approved by the European Commission on January 7, 2021.[L45241] … More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: XOFLUZA 40 MG FİLM KAPLI TABLET, 1 ADET, XOFLUZA 20 MG FİLM KAPLI TABLET, 2 ADET
  6. Target

    Intracellular exo-alpha-(1->5)-L-arabinofuranosidase

    go.drugbank.com/bio_entities/BE0001766
    TargetGeobacillus stearothermophilus

    Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (branched and debranched arabinans).

    Polypeptides: Intracellular exo-alpha-(1->5)-L-arabinofuranosidaseSynonyms: Intracellular arabinan exo-alpha-(1->5)-L-arabinosidase
  7. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase

    go.drugbank.com/bio_entities/BE0004887
    EnzymeTargetHumans

    Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: 5 alpha-SR2, Steroid 5-alpha-reductase 1
  8. Target

    Tumor necrosis factor receptor superfamily member 5

    go.drugbank.com/bio_entities/BE0001196
    TargetHumans

    Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

    Polypeptides: Tumor necrosis factor receptor superfamily member 5
  9. Target

    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

    go.drugbank.com/bio_entities/BE0001223
    TargetHumans

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibitin...

    Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  10. Target

    Sodium channel protein type 5 subunit alpha

    go.drugbank.com/bio_entities/BE0000197
    TargetHumans

    Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...

    Polypeptides: Sodium channel protein type 5 subunit alpha