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Displaying results 371 - 380 of 2743 in total
  1. Target

    Holliday junction branch migration complex subunit RuvB

    go.drugbank.com/bio_entities/BE0002792
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    forks via replication fork reversal (RFR). … The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication

    Polypeptides: Holliday junction branch migration complex subunit RuvB
  2. Target

    Cytochrome b-c1 complex subunit 2, mitochondrial

    go.drugbank.com/bio_entities/BE0003855
    TargetHumans

    The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP … The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase

    Polypeptides: Cytochrome b-c1 complex subunit 2, mitochondrialSynonyms: Ubiquinol-cytochrome-c reductase complex core protein 2, Core protein II
  3. Target

    Cytochrome b-c1 complex subunit 6, mitochondrial

    go.drugbank.com/bio_entities/BE0003856
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.

    Polypeptides: Cytochrome b-c1 complex subunit 6, mitochondrialSynonyms: Complex III subunit 6, Complex III subunit VIII
  4. Target

    Inner membrane complex sub-compartment protein 3

    go.drugbank.com/bio_entities/BE0009269
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Inner membrane complex sub-compartment protein 3
  5. Drug

    Anvatabart opadotin

    go.drugbank.com/drugs/DB18290
    Investigational

    Synonyms: sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via
  6. Drug

    Brexanolone

    go.drugbank.com/drugs/DB11859
    ApprovedInvestigational

    brexanolone may also be undergoing clinical trials to investigate its abilities to treat super-refractory status epilepticus, it appears that some such studies have failed to meet primary endpoints that compare

  7. Drug

    Letermovir

    go.drugbank.com/drugs/DB12070
    ApprovedInvestigational

    Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. … [L1021] It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors.[A31290] Letermovir has recieved both priority and orphan drug status from the FDA.

    Categories: DNA Terminase Complex Inhibitors, Cytomegalovirus DNA Terminase Complex Inhibitor
  8. Drug

    Norgestimate

    go.drugbank.com/drugs/DB00957
    ApprovedInvestigational

    Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with eth...

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  9. Drug

    Donepezil

    go.drugbank.com/drugs/DB00843
    ApprovedInvestigational

    In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholineste...

  10. Target

    Holliday junction branch migration complex subunit RuvB

    go.drugbank.com/bio_entities/BE0001514
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    forks via replication fork reversal (RFR). … The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication

    Polypeptides: Holliday junction branch migration complex subunit RuvB