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Telithromycin
go.drugbank.com/drugs/DB00976ApprovedBinding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. … Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides.
Categories: Erythromycin and similars, Macrolides, Lincosamides and StreptograminsProducts: KETEK ® 400 MGCopper gluconate
go.drugbank.com/drugs/DB11246ApprovedInvestigationalAccording to the good manufacturing or feeding practice by the FDA, copper gluconate is used as a nutrient or dietary supplement and is generally recognized as safe for use at a level not exceeding 0.005 … Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color.
Mixtures: Pregnancy Multivitamin Folic 5, Super 7 Vitamin and Mineral SupplementProducts: Copper (gluconate) 2 Mg TabletsTreosulfan
go.drugbank.com/drugs/DB11678ApprovedInvestigationalTreosulfan is a prodrug alternative to [busulfan] for myeloablative conditioning prior to hematopoietic stem cell transplantation. … [L52245] It was approved by the EMA in June 2019[L16965] and by the FDA in January 2025 for use in combination with [fludarabine].[L52575]
Categories: Antineoplastic and Immunomodulating Agents, Cytochrome P-450 SubstratesSynonyms: L-threitol-1,4-dimethanesulfonateNeratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalNeratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer.
Synonyms: 奈拉替尼Categories: Antineoplastic and Immunomodulating Agents, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexTolfenamic acid
go.drugbank.com/drugs/DB09216ApprovedTolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. … It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSProducts: TOLFEDINE TABLET 60 MG, TOLFEDINE TABLETS 6 MGBufexamac
go.drugbank.com/drugs/DB13346ApprovedWithdrawnBufexamac is a non-steroidal anti-inflammatory drug (NSAID) under the market name Droxaryl, Malipuran, Paraderm and Parfenac. … The use of bufexamac has been discontinued in Canada and the United States, which may be due to undetermined clinical efficacy and a high prevalence of contact sensitization [A32822].
Categories: Non COX-2 selective NSAIDS, Acetic Acid Derivatives and Related SubstancesSynonyms: 4-Butoxy-N-hydroxybenzeneacetamide, 2-(p-Butoxyphenyl)-acetohydroxamic acidPizotifen
go.drugbank.com/drugs/DB06153ApprovedPizotifen belongs to the class of antamines and is related to [cyproheptadine].[A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. … Sandomigran is available in a number of countries but is not approved by the FDA nor EMA.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-1 Receptor AntagonistsProducts: SANDOMIGRAN 0,5 MG KAPLI TABLET, 30 ADET, Pizogran Tablet 0.5 mgProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
go.drugbank.com/bio_entities/BE0000087TargetHumansPart of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine r...
Polypeptides: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Gamma-aminobutyric acid receptor subunit alpha-5
go.drugbank.com/bio_entities/BE0000471TargetHumansExtrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity) … GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-5Synonyms: GABAAR subunit alpha-5, GABA(A) receptor subunit alpha-51-deoxy-D-xylulose 5-phosphate reductoisomerase
go.drugbank.com/bio_entities/BE0001575TargetEscherichia coli (strain K12)Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Polypeptides: 1-deoxy-D-xylulose 5-phosphate reductoisomeraseSynonyms: 1-deoxyxylulose-5-phosphate reductoisomerase