Gamma-aminobutyric acid receptor subunit alpha-5

BE0000471ProteinHumansGABRA5

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). It is acted on by 26 drugs in DrugBank.

Gene name
GABRA5
UniProtKB entry
P31644Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
462 residues · 52,146 Da
Also known as
GABA(A) receptor subunit alpha-5 · GABAAR subunit alpha-5

Resolves to

Protein
UniProtP31644UniProt nameGBRA5_HUMAN
Gene
HGNCHGNC:4079NCBI Gene2558GenBank182916GeneCardsGABRA5
Pharmacology
IUPHAR/GtoPdb408KEGGhsa:2558
Structure
PDB5O8FPDB5OJMPDB6A96
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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66+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-5, how selective are they, and which programs against it are still in active trials?

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