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Displaying results 3841 - 3850 of 10000 in total
  1. Drug

    Estradiol

    go.drugbank.com/drugs/DB00783
    ApprovedInvestigationalVet approved

    Estradiol is a naturally occurring hormone circulating endogenously in females. … Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain.

    Synonyms: 17-β estradiolInternational brands: Estraderm MX
  2. Drug

    2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE

    go.drugbank.com/drugs/DB04736
    Experimental

    Synonyms: 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE
  3. Drug

    Zebularine

    go.drugbank.com/drugs/DB03068
    Experimental

    A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. … Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

    Synonyms: 4-deoxyuridine, 1-beta-D-ribofuranosyl-2(1H)-pyrimidinoneCategories: Heterocyclic Compounds, 1-Ring
  4. Drug

    Calcimycin

    go.drugbank.com/drugs/DB19408
    Investigational

    Primarily used as a biochemical tool for studying divalent cations in biological systems, Calcimycin also exhibits antibiotic activity against gram-positive bacteria and fungi. … It binds to and transports calcium and other divalent cations across membranes, disrupts oxidative phosphorylation, and inhibits ATPase in rat liver mitochondria.

    Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 2-RingSynonyms: 4-benzoxazolecarboxylic acid, 5-(methylamino)-2-(((2r,3r,6s,8s,9r,11r)-3,9,11-trimethyl-8-((1s)-1-methyl-2-oxo-2-(1h-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, 5-(methylamino)-2-(((2r,3r,6s,8s,9r,11r)-3,9,11-trimethyl-8-((1s)-1-methyl-2-oxo-2-(1h-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-4-benzoxazolecarboxylic acid
  5. Drug

    Mapatumumab

    go.drugbank.com/drugs/DB18945
    Investigational

    Mapatumumab is under investigation in clinical trial NCT00094848 (Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-hodgkin's Lymphoma (NHL)).

    Synonyms: Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receceptor 4)) (human monoclonal trm-1 heavy chain), disulfide with human monoclonal trm-1 .lambda.-chain, dimer, Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receceptor 4)) (human monoclonal trm-1 heavy chain), disulphide with human monoclonal trm-1 .lambda.-chain, dimer
  6. Drug

    Vilastobart

    go.drugbank.com/drugs/DB19327
    Investigational

    Vilastobart is under investigation in clinical trial NCT04896697 (Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors).

    Synonyms: immunoglobulin G1-fused prodomain kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody, gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV1-69*08 (84.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT[8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, D12, L14,
  7. Drug

    Paclitaxel

    go.drugbank.com/drugs/DB01229
    ApprovedInvestigationalVet approved

    Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel … Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexSynonyms: -HYDROXY-, (2AR,4S,4AS,6R,9S,11S,12S,12AR,12BS)-6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA(3, Taxol A
  8. Drug

    Latrunculin A

    go.drugbank.com/drugs/DB02621
    Investigational

    Latrunculin A is an actin binding macrolide purified from the red sea sponge Latrunculia magnifica. It is under investigation for the treatment of cancer.

    Synonyms: (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one, LAT-A
  9. Drug

    Montelukast

    go.drugbank.com/drugs/DB00471
    ApprovedInvestigational

    worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product. … [L6301] The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.

    Mixtures: AIRCOMB 2,5 MG/4 MG GRANÜL İÇEREN SAŞE, 30 ADET, AIRCOMB 2,5 MG/4 MG GRANÜL İÇEREN SAŞE, 90 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  10. Drug

    N-Acetylmethionine

    go.drugbank.com/drugs/DB01646
    Investigational

    Synonyms: (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid, L-(N-Acetyl)methionineMixtures: AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2000 ML TEKLİ TORBA, AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML ÇİFTLİ TORBA