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Norethisterone
go.drugbank.com/drugs/DB00717ApprovedInvestigational[A10367] Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency,[A188075] and is used on its own or in combination with estrogen derivatives in a variety of applications … Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.
Synonyms: 17-α-ethynyl-19-norandrost-4-en-17-β-ol-3-one, 17-α-ethynyl-4-estren-17-ol-3-oneInternational brands: Primolut-NGivosiran
go.drugbank.com/drugs/DB15066ApprovedGivosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. … [L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder
Categories: Heterocyclic Compounds, 1-Ring, Aminolevulinate Synthase 1-directed RNA InteractionTovorafenib
go.drugbank.com/drugs/DB15266ApprovedInvestigationalTovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. … [A263597] It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements.
Synonyms: 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-, 6-Amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamideCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersOBE101
go.drugbank.com/drugs/DB05080ExperimentalOBE101 is a new weight loss drug developed by Obecure Ltd. It is a new formulation that is based on the vertigo medication, Betahistine.
Tezepelumab
go.drugbank.com/drugs/DB15090ApprovedInvestigationalAsthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. … [A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes.
Products: TEZSPIRE®, Tezspire 210 mg/1,91 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem (1 adet)Flavin mononucleotide
go.drugbank.com/drugs/DB03247ApprovedInvestigational[L54226] In addition to its systemic use as a means of riboflavin supplementation, a topical ophthalmic preparation of FMN was approved by the FDA in October 2025 for use as a photoenhancer in epithelium-on … [A274616,L54226] FMN is composed of an isoalloxazine ring - which serves as the active redox center - attached to a ribityl phosphate chain.
Salts: Riboflavin 5'-phosphate sodium anhydrous, Riboflavin-5'-phosphate sodium salt dihydrateMixtures: B-KOMP ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL, 5 ADET, Alsimine W Vitamins A DGlisoxepide
go.drugbank.com/drugs/DB01289InvestigationalGlisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesDaridorexant
go.drugbank.com/drugs/DB15031ApprovedInvestigationalConventional treatments for insomnia include drugs targeting gamma-aminobutyric acid type-A (GABA-A), serotonin, histamine, or melatonin receptors; however, undesirable side effects are frequently reported … Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDexpanthenol
go.drugbank.com/drugs/DB09357ApprovedInvestigationalDexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. … Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism
Synonyms: D-panthenol, (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamideMixtures: B-KOMP ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPUL, 5 ADET, Alsimine W Vitamins A DPlitidepsin
go.drugbank.com/drugs/DB04977InvestigationalAplidine is also of interest as a potential treatment for some leukemias. … Aplidine is a peptide found in tunicates which shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. The specific marine organism is _Aplidium albicans_.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesSynonyms: Dehydrodidemnin B