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Sennosides
go.drugbank.com/drugs/DB11365ApprovedInvestigationalSennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and empty the large intestine before surgery. … The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth[FDA Label].
Salts: Sennosides A and BMixtures: Senna and Docusate Sodium, Senna and Docusate SodiumLactulose
go.drugbank.com/drugs/DB00581ApprovedInvestigational[L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health … [L6202] Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the fact that lactulose therapy cannot be ethically
Categories: Alimentary Tract and MetabolismSynonyms: 4-O-beta-D-Galactopyranosyl-D-fructose, 4-O-beta-D-Galactopyranosyl-D-fructofuranoseMeradimate
go.drugbank.com/drugs/DB11096Approved[T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products. … Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.
Mixtures: Principal Secret Reclaim Sunscreen For Face and Body SPF 30, Laura mercier Tinted Moisturizer SPF-20 SandSynonyms: Menthyl-O-aminobenzoateCyproterone acetate
go.drugbank.com/drugs/DB04839ApprovedInvestigationalIt is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. … An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties.
Mixtures: OC - 35, DONABELLA® 2 MG /0.035 MGCategories: Sex Hormones and Modulators of the Genital System, Antiandrogens and EstrogensAcetylcholine
go.drugbank.com/drugs/DB03128ApprovedInvestigationalAcetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in … It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.
Categories: Antiglaucoma Preparations and MioticsSynonyms: O-AcetylcholineMephenesin
go.drugbank.com/drugs/DB13583ApprovedWithdrawnMephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression [A32760]. It first entered use in the 1950s.
Synonyms: 3-(O-METHYLPHENOXY)-1,2-PROPANEDIOLFloretyrosine F 18
go.drugbank.com/drugs/DB15405ApprovedInvestigationalFET F-18 is under investigation in clinical trial NCT01756352 (FET-PET for Evaluation of Response of Recurrent GBM to Avastin).
Categories: fluoroethyl-L-tyrosine (18F)Synonyms: O-(2-FLUOROETHYL)-L-TYROSINE F-18, O-(2-[18F]Fluoroethyl)-L-tyrosinePenicillium glaucum
go.drugbank.com/drugs/DB14171ApprovedPenicillium glaucum allergenic extract is used in allergenic testing.
Synonyms: Molds, rusts and smuts, penicillium glaucum, Molds, rusts and smuts, penicillium glaucusMixtures: Molds - Mold Mix 4Obecabtagene autoleucel
go.drugbank.com/drugs/DB17362ApprovedInvestigationalObecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [L52450] Obecabtagene autoleucel was also investigated in other hematological cancers and systemic lupus erythematosus.[A265045]
Categories: Antineoplastic cell and gene therapy, Antineoplastic and Immunomodulating AgentsSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, SELF-INACTIVATING LENTIVIRAL VECTOR CONSISTING OF 5' FUSION BETWEEN THE CMV PROMOTER AND HIV LTR, WHERE THE CMV PROMOTER REPLACES THE U3 REGION.Tofersen
go.drugbank.com/drugs/DB14782ApprovedInvestigational[A259023] However, it could potentially be due to the short timeframe of tofersen treatment, and more longterm trials are being conducted to confirm this hypothesis.[A259023] … [L52735] Tofersen demonstrated efficacy in reducing the concentration of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks, although the ALS Functional Rating Scale–Revised did not
Categories: Nucleic Acids, Nucleotides, and NucleosidesSynonyms: DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP, -(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))R