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Displaying results 31 - 40 of 597 in total
  1. Pathway

    Bumetanide Diruretic Action Pathway

    smpdb.ca/view/SMP0124517
    Drug action

    Bumetanide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Bumetanide · Potassium cation
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Chlorothiazide Action Pathway

    smpdb.ca/view/SMP0123141
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Chlorothiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Bendroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000090
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Bendroflumethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  4. Pathway

    Polythiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123144
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Polythiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Cyclothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123145
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Cyclothiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Benzthiazide Action Pathway

    smpdb.ca/view/SMP0126366
    Drug action

    This inhibition of the cotransporter results in the increased excretion of sodium, chloride, and, in consequence, water. … This drug is used in the treatment of hypertension and edema. They act on the kidneys by inhibiting the sodium-chloride reabsorption (via the Na+/Cl- cotransporter) from its early distal tubules.

    Drugs: Benzthiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Hydroflumethiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123142
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Hydroflumethiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Chlorthalidone Diuretic Action Pathway

    smpdb.ca/view/SMP0123149
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Chlorthalidone · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  9. Pathway

    Methyclothiazide Action Pathway

    smpdb.ca/view/SMP0000081
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Methyclothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  10. Pathway

    Hydroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000108
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Hydroflumethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka