Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the... Thiazides also cause loss of potassium and an increase in serum uric acid.
- Mechanism
- Curator reviewed
As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
- Primary indication
- For the treatment of high blood pressure and management of edema.Curator reviewed
- Formula / weight
- C15H14ClN3O4S3 · 431.937 g/mol (avg)
- Code names
- P 1393
Resolves to
NDTSRXAMMQDVSW-UHFFFAOYSA-NSMILESNS(=O)(=O)C1=CC2=C(C=C1Cl)N=C(CSCC1=CC=CC=C1)NS2(=O)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Benzthiazide, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account