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Displaying results 31 - 40 of 178 in total
  1. Target

    Mitogen-activated Protein Kinases

    go.drugbank.com/bio_entities/BE0009853
    TargetHumans

    MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells

    Synonyms: Insulin-stimulated MAP2 kinase
  2. Target

    Glucose-dependent insulinotropic receptor

    go.drugbank.com/bio_entities/BE0003378
    TargetHumans

    Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

    Polypeptides: Glucose-dependent insulinotropic receptor
  3. Target

    Islet amyloid polypeptide

    go.drugbank.com/bio_entities/BE0000921
    TargetHumans

    Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

    Synonyms: Insulinoma amyloid peptide
  4. Target

    Protein kinase C epsilon type

    go.drugbank.com/bio_entities/BE0003431
    TargetHumans

    May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. … In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF.

  5. Target

    Protein kinase C

    go.drugbank.com/bio_entities/BE0004895
    TargetEnzymeHumans

    In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. … In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade.

  6. Target

    Endosialin

    go.drugbank.com/bio_entities/BE0010752
    TargetHumans

    Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. … In human, negatively regulates T-cell proliferation compared with stromal cells where it increases proliferation (PubMed:21466550)

  7. Target

    Gastric inhibitory polypeptide receptor

    go.drugbank.com/bio_entities/BE0011012
    TargetHumans

    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

    Synonyms: Glucose-dependent insulinotropic polypeptide receptor
  8. Target

    Bifunctional purine biosynthesis protein ATIC

    go.drugbank.com/bio_entities/BE0001240
    TargetEnzymeHumans

    Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571) … Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775).

  9. Target

    Cell adhesion molecule CEACAM1

    go.drugbank.com/bio_entities/BE0000107
    TargetHumans

    Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). … Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis.

  10. Target

    ATP-binding cassette sub-family C member 8

    go.drugbank.com/bio_entities/BE0000207
    TargetTransporterHumans

    Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release.