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Pyrithione
go.drugbank.com/drugs/DB06815ApprovedInvestigationalPyrithione zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. … While its use has been approved in the early 1960's by the FDA [A32163], safety and effectiveness of pyrithione zinc has been reported for decades.
Mixtures: Head and Shoulders Dual Sachets Full and Strong, Head and Shoulders Dual Sachets Full and StrongSynonyms: Pyridinethiol N-oxideEsomeprazole
go.drugbank.com/drugs/DB00736ApprovedInvestigationalEsomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … It can also be found in quadruple regimens for the treatment of _H. pylori_ infections along with other antibiotics including [DB01060], [DB01211], and [DB00916], for example.
Mixtures: VIMOVO 500MG/20MG MODIFIED-RELEASE TABLETS, Naproxen and esomeprazole magnesiumCategories: Alimentary Tract and Metabolism, Omeprazole and enantiomerDicyclomine
go.drugbank.com/drugs/DB00804ApprovedInvestigationalDicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder … and irritable bowel syndrome.
Categories: Alimentary Tract and MetabolismProducts: Bentylol Inj 10mg/ml, Viscerol Cap 10mgAmitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. … [A259342] Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.[A174661]
Mixtures: Perphenazine and Amitriptyline Hydrochloride, Perphenazine and Amitriptyline HydrochlorideCategories: amitriptyline and psycholeptics, Tricyclics and Other Norepinephrine-reuptake InhibitorsIsosorbide dinitrate
go.drugbank.com/drugs/DB00883ApprovedInvestigationalA vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Mixtures: Isosorbide dinitrate and hydralazine hydrochloride, Isosorbide Dinitrate and Hydralazine HydrochlorideCategories: Vasodilators Used in Cardiac Diseases, Nitrates and NitritesBaclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigational[A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977. … Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients.
Categories: Amino Acids, Peptides, and ProteinsProducts: LIORESAL 25MG, LIORESAL 10MGRitodrine
go.drugbank.com/drugs/DB00867ApprovedWithdrawnAdrenergic beta-agonist used to control premature labor.
Categories: Genito Urinary System and Sex HormonesProducts: Yutopar Tab 10mg, Yutopar Inj 50mg/5mlFexofenadine
go.drugbank.com/drugs/DB00950ApprovedInvestigationalFexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. … [L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation
Mixtures: Foster and Thrive Allergy and Congestion D, Allergy and CongestionProducts: Up and Up Allergy Relief, Up and Up Non Drowsy Allergy ReliefDimenhydrinate
go.drugbank.com/drugs/DB00985ApprovedInvestigational[L32995] Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. … Dimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950.
Synonyms: N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate, 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)Products: Dimenhydrinate Inj 10mg/ml, Dimenhydrinate Injection USP 250mg/5ml (50mg/ml)Esmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnIt works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. … It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses.
Products: Brevibloc Liq IV 250mg/ml, Brevibloc Liq IV 10mg/ml