Dicyclomine is an antimuscarinic agent used to treat IBS. Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.
- Mechanism
- Curator reviewed · 5 references
Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine. Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.
- Primary indication
- Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.Curator reviewed · 3 structured indications
- Formula / weight
- C19H35NO2 · 309.4867 g/mol (avg)
- First approval
- Canada, 2004 · United States, 1950
- Also known as
- Dicycloverin · Dicycloverine
- Brand names
Resolves to
CURUTKGFNZGFSE-UHFFFAOYSA-NSMILESCCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Dicyclomine, and which of those have an active Phase 3 trial?
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