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Cyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigational[A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond. … [A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
Mixtures: Cyclo/Gaba 10/300 Pack, Cyclo/MagCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCanakinumab
go.drugbank.com/drugs/DB06168ApprovedInvestigationalIt is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. … Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass.
Products: ILARIS® SOLUCIÓN INYECTABLE 150 MG/ ML, İLARİS 150 MG/ML ENJEKSİYONLUK ÇÖZELTİ, 1 ADETSpironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.
Mixtures: SPIRO D TABLINEN 100MG, AKTAZİD 50 MG/50 MG FİLM KAPLI TABLET, 100 ADETCategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsOctreotide
go.drugbank.com/drugs/DB00104ApprovedInvestigationalAcromegaly is a life-threatening disease requiring life-long management. … [L14501] In most cases, it results from an anterior pituitary growth hormone-releasing tumor.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: SANDOSTATIN LAR 10 MG, SANDOSTATIN LAR FOR INJECTION 10 mgCalcium
go.drugbank.com/drugs/DB01373ApprovedInvestigationalNutraceuticalBone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. … The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions.
Mixtures: Port A Mins Super Cal-mag 300/150 With Vitamin D3, Calcium With Vitamin D 200 Mg/160 IuProducts: Tall G U, Ag-XAlbendazole
go.drugbank.com/drugs/DB00518ApprovedInvestigationalVet approvedA benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Mixtures: AH MICOL, AH-MICOLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersPinaverium
go.drugbank.com/drugs/DB09090ApprovedInvestigationalPinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. … Pinaverium bromide is the common ingredient in formulations, mostly as oral tablets.
Mixtures: BROMUX D® 100/300 MG CÁPSULA., DICETEL-DUOCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNitrofurantoin
go.drugbank.com/drugs/DB00698ApprovedInvestigationalVet approved[L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. … Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.
Products: Nu-nitrofurantoin Tablets, AA-Nitrofurantoin Tablet 100mgMidazolam
go.drugbank.com/drugs/DB00683ApprovedIllicitInvestigational[A257153] Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] … [A173842] It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: N/a, MIDAZOLAM 15 MG/ 3 MLDopamine
go.drugbank.com/drugs/DB00988ApprovedInvestigationalDopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Mixtures: INYECCION DE CLORHIDRATO DE DOPAMINA 800 MCG/ML DEXTROSA AL 5% UPS, INYECCION DE CLORHIDRATO DE DOPAMINA EN DEXTROSA AL 5% USP (1600 MCG/ML)Categories: Monoamine Oxidase A Substrates, Compounds used in a research, industrial, or household setting