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Mitogen-activated protein kinase kinase kinase 20
go.drugbank.com/bio_entities/BE0005595TargetHumansMay be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622) … Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation
Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZKInfluenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB15515ApprovedVaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.
Mixtures: Influvac Tetra, suspension for injection in pre-filled syringe, INFLUVAC TETRA, SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE 0.5 MLNicergoline
go.drugbank.com/drugs/DB00699ApprovedAn ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Categories: Ergot Alkaloids and DerivativesTelithromycin
go.drugbank.com/drugs/DB00976ApprovedBinding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. … Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis.
Categories: Erythromycin and similars, Macrolides, Lincosamides and StreptograminsPegunigalsidase alfa
go.drugbank.com/drugs/DB14992ApprovedInvestigationalby the deficiency of alpha-galactosidase A. … While agalsidase alfa and agalsidase beta enter lysosomes via the mannose-6-phosphate (M6P) receptor, pegunigalsidase alfa carries no M6P on its glycans and does not depend on the M6P receptor during cellular
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismRenzapride
go.drugbank.com/drugs/DB04917InvestigationalIt has been suggested that renzapride is effective in the treatment of irritable bowel syndrome with alternating stool pattern. It is being developed by Alizyme of the UK. … Renzapride is currently in Phase III clinical development in the United States for the treatment of constipation-predominant irritable bowel syndrome (IBS-C).
4'-Methylene-5,8,10-trideazaaminopterin
go.drugbank.com/drugs/DB05616InvestigationalCH-1504 is a an antirheumatic agent that has been shown in vitro to be a nonpolyglutamylatable and nonhydroxylatable antifolate that is more efficiently taken up into cells by the reduced folate carrier … It has been investigated for the treatment of Rheumatoid Arthritis (phase II).
Tisotumab vedotin
go.drugbank.com/drugs/DB16732ApprovedInvestigationalEach monoclonal antibody molecule carries an average of four MMAE molecules. Tisotumab vedotin is the first TF-directed ADC [A238914] that works by binding to TFs expressed on solid tumours. … The approval was based on tumour response and the durability of the response as demonstrated in InnovaTV 204 (NCT03438396): in this trial, the objective response rate was 24% and the median response duration
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsMafenide
go.drugbank.com/drugs/DB06795ApprovedVet approvedWithdrawnIn November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements … Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
Categories: Genito Urinary System and Sex Hormones, Gynecological Antiinfectives and Antiseptics