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Displaying results 4141 - 4150 of 10000 in total
  1. Drug

    Tamsulosin

    go.drugbank.com/drugs/DB00706
    ApprovedInvestigational

    Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common. … [Label] Other alpha-1 adrenoceptor antagonists developed in the 1980s were less selective and more likely to act on the smooth muscle of blood vessels, resulting in hypotension.

    Synonyms: (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide, (R)-(−)-tamsulosinInternational brands: Harnal D
  2. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
  3. Drug

    Acetylsalicylic acid

    go.drugbank.com/drugs/DB00945
    ApprovedInvestigationalVet approved

    Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. … Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations

    Mixtures: KLOGEL-A 75/75 MG KAPSUL, 30 ADET, KLOGEL-A 75/75 MG KAPSUL, 90 ADETCategories: P-glycoprotein inducers, P-glycoprotein substrates
  4. Drug

    Fish liver oil

    go.drugbank.com/drugs/DB15481
    ApprovedWithdrawn

    Mixtures: A+ Zinc Tab, Formula F L WProducts: Vitamine A 10000 U.I., Vitamine A 10000ui Capsule
  5. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. … Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the

    Mixtures: TRAMADOLO E PARACETAMOLO EG, TRAMADOLO E PARACETAMOLO EGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Venlafaxine

    go.drugbank.com/drugs/DB00285
    ApprovedInvestigational

    It was also considered a second-line treatment for obsessive-compulsive disorder (OCD). … [A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: VENOXOR®75 MG, EFEXOR® XR 37.5 MG CAPSULAS
  7. Drug

    Dextrose, unspecified form

    go.drugbank.com/drugs/DB09341
    ApprovedInvestigationalVet approved

    L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.

    Mixtures: Delflex A Perit.dial.soln W.4.25%dext.low mg, Delflex A Perit.dial.solN.W.1.5%dext.low mgCategories: Compounds used in a research, industrial, or household setting
  8. Pathway

    Acylcarnitine (4Z,7Z,10S,11E)-10-hydroperoxy-12-[(1R,4S,5S,6R)-6-[(2Z)-pent-2-en-1-yl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl]dodeca-4,7,11-trienoylcarnitine

    smpdb.ca/view/SMP0123477
    Metabolic

    Once inside the cell it undergoes a reaction to form an acyl-CoA derivative called (4Z,7Z,10S,11E)-10-hydroperoxy-12-[(1R,4S,5S,6R)-6-[(2Z)-pent-2-en-1-yl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl]dodeca-4,7,11 … This reaction is facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate acyl groups.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  9. Drug

    Leuprolide

    go.drugbank.com/drugs/DB00007
    ApprovedInvestigational

    [A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename Lupron™ by Abbvie Endocrine Inc. … Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH).

    International brands: Prostap 3Products: ELIGARD 22.5 MG ENJ. COZ. ICIN S.C. TOZ ICEREN SIRINGA VE COZUCU ICEREN SIRINGA, 1 ADET, LUPRON ® DEPOT 11.25 MG POLVO LIOFILIOZADO PARA RECONSTITUIR A SUSPENSIÓN INYECTABLE
  10. Target

    Nectin-4

    go.drugbank.com/bio_entities/BE0009798
    TargetHumans

    Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells

    Polypeptides: Nectin-4Synonyms: Nectin cell adhesion molecule 4, Poliovirus receptor-related protein 4