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Displaying results 4191 - 4200 of 10000 in total
  1. Target

    Eukaryotic translation initiation factor 6

    go.drugbank.com/bio_entities/BE0008972
    TargetHumans

    Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimula...

    Polypeptides: Eukaryotic translation initiation factor 6Synonyms: eIF-6
  2. Target

    Probable ATP-dependent 6-phosphofructokinase

    go.drugbank.com/bio_entities/BE0009180
    TargetPlasmodium falciparum (isolate 3D7)

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

    Polypeptides: Probable ATP-dependent 6-phosphofructokinaseFunction: 6-phosphofructokinase activity
  3. Target

    Ephrin type-B receptor 6

    go.drugbank.com/bio_entities/BE0009442
    TargetHumans

    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation...

    Polypeptides: Ephrin type-B receptor 6Synonyms: Tyrosine-protein kinase-defective receptor EPH-6
  4. Target

    Growth arrest-specific protein 6

    go.drugbank.com/bio_entities/BE0010201
    TargetHumans

    Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell su...

    Polypeptides: Growth arrest-specific protein 6Synonyms: GAS-6
  5. Drug

    Fulvestrant

    go.drugbank.com/drugs/DB00947
    ApprovedInvestigational

    Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. … While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol
  6. Drug

    Magrolimab

    go.drugbank.com/drugs/DB16225
    Investigational

    Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).

    Synonyms: Immunoglobulin g4(225-proline), anti-(human cd47 antigen) (human-mus musculus monoclonal hu5f9-g4 .gamma.4-chain), disulfide with human-mus musculus monoclonal hu5f9-g4 .kappa.-chain, dimer, )) (8.8.10) (1-117)-homo sapiens ighg4*01 (ch1 (118-2
  7. Drug

    Sabatolimab

    go.drugbank.com/drugs/DB16322
    Investigational

    Sabatolimab is under investigation in clinical trial NCT03946670 (A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With IPSS-R Intermediate, High or Very High Risk Myelodysplastic

    Synonyms: Immunoglobulin g4 (226-proline,de-c-terminal-lysine), anti-(human hepatitis virus a cellular receptor 2) (human-mus musculus monoclonal clone nvs260714 .gamma.4-chain), disulfide with human-mus musculus, Immunoglobulin g4-kappa, anti-(homo sapiens havcr2 (hepatitis a virus cellular receptor 2, t-cell immunoglobulin mucin family member 3, tim-3, tim3, timd3, cd366)), humanized monoclonal antibody
  8. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0000455
    TargetHumans

    In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs (PubMed:10942115) … Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism (PubMed:10942115, PubMed:1339442, PubMed:34047349, PubMed:37794595).

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseSynonyms: 4-hydroxyphenylpyruvic acid oxidase, N(6)-adenosine-methyltransferase HPD
  9. Target

    Integrin alpha-4

    go.drugbank.com/bio_entities/BE0000590
    TargetHumans

    Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. … Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.

    Polypeptides: Integrin alpha-4Synonyms: VLA-4 subunit alpha
  10. Target

    Integrin beta-4

    go.drugbank.com/bio_entities/BE0003298
    TargetHumans

    Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

    Polypeptides: Integrin beta-4