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Cyclin-dependent kinase 15
go.drugbank.com/bio_entities/BE0000437TargetHumansSerine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'
Synonyms: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 proteinPeroxiredoxin-1
go.drugbank.com/bio_entities/BE0005844TargetEnzymeHumansThiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor o...
Synonyms: Proliferation-associated gene proteinAVR-RD-01
go.drugbank.com/drugs/DB17651InvestigationalAVR-RD-01 is an investigational _ex vivo_ lentiviral gene therapy developed by AVROBIO Inc. … It consists of autologous CD34+ cells that transduced with Lentiviral Vector/alpha-galactosidase A (AGA) encoding for the human AGA complementary deoxyribonucleic acid (cDNA) sequence.
Picrotoxin
go.drugbank.com/drugs/DB00466ExperimentalAlthough it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem] … A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore.
Categories: GABA-A Receptor Antagonists, Compounds used in a research, industrial, or household setting3,4-Methylenedioxy-N-isopropylamphetamine
go.drugbank.com/drugs/DB06112ExperimentalMDI-P has demonstrated potent anti-HIV activity. MDI-P has been shown to be effective in killing HIV in cell culture. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). … MDI-P is also a potential therapeutic agent for the treatment of the symptoms of cystic fibrosis ("CF").
Synonyms: MDI-P, 3,4-Methylenedioxy-N-isopropylamphetamineProteasome subunit beta type-9
go.drugbank.com/bio_entities/BE0004737TargetHumansThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (PubMed:33727065, PubMed:348195...
Synonyms: Really interesting new gene 12 proteinTransforming growth factor beta activator LRRC32
go.drugbank.com/bio_entities/BE0014554TargetHumansKey regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). As...
Synonyms: Leucine-rich repeat-containing protein 32Function: receptor ligand inhibitor activityECT-001 expanded cord blood
go.drugbank.com/drugs/DB21745InvestigationalECT-001 expanded cord blood is umbilical cord blood (UCB) that has been co-cultured and expanded with the small molecule agonist [UM-171].
Tranilast
go.drugbank.com/drugs/DB07615InvestigationalIt has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: N-(3,4-Dimethoxycinnamoyl)anthranilic acidVamotinib
go.drugbank.com/drugs/DB15396Investigationalnd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Gene). … NCT02885766 (Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-
Categories: Heterocyclic Compounds, 1-Ring