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Displaying results 4251 - 4260 of 10000 in total
  1. Drug

    Thenoyltrifluoroacetone

    go.drugbank.com/drugs/DB04795
    Experimental

    Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration.

    Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingSynonyms: 1,1,1-Trifluoro-3-(2-thenoyl)acetone, 2-Thenoyltrifluoroacetone
  2. Drug

    RAV12

    go.drugbank.com/drugs/DB05140
    Investigational

    RAV12 is investigated for use/treatment in solid tumors. RAV12 is a solid. … RAV12 is a chimeric antibody that recognizes RAAG12, an N-linked carbohydrate antigen found on gastric, colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells.

  3. Pathway

    mTOR Signaling pathway

    smpdb.ca/view/SMP0535455
    Signaling

    as rapamycin and its analogs—has shown efficacy in cancer and aging models but may also perturb immune function and metabolic homeostasis. … the Ragulator–Rag GTPase complex to promote RagA/B‑GTP formation and mTORC1 lysosomal localization; and glutamine activates mTORC1 via a Rag-independent mechanism requiring the Arf1 GTPase (and Rab1A in

    Drugs: Arginine · L-Glutamine · Leucine · ATP · Magnesium cation · Zinc
    Enzymes: V-type proton ATPase subunit e 2
  4. Drug

    SN-38

    go.drugbank.com/drugs/DB05482
    Investigational

    7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer … SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.

    Categories: Topoisomerase I Inhibitors, Cytochrome P-450 SubstratesSynonyms: 1H-PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4,11-DIETHYL-4,9-DIHYDROXY-, (4S)-, IRINOTECAN RELATED COMPOUND B
  5. Drug

    Ligelizumab

    go.drugbank.com/drugs/DB11856
    Investigational

    Ligelizumab is a humanized IgG1k monoclonal antibody targeted against immunoglobulin E (IgE). … Similar in mechanism to [omalizumab], another IgE-directed monoclonal antibody, ligelizumab has a distinct binding epitope as compared to its peer (with a small degree of overlap) which appears to confer

  6. Drug

    Metiamide

    go.drugbank.com/drugs/DB08805
    Experimental

    Metiamide is an H-2 receptor antagonist derived from burimamide. It was an intermediate product on the path to developing cimetidine.

  7. Drug

    Maltotetraose

    go.drugbank.com/drugs/DB02237
    Experimental

    Categories: Compounds used in a research, industrial, or household setting
  8. Drug

    Lyme disease vaccine (recombinant OspA)

    go.drugbank.com/drugs/DB00045
    ApprovedWithdrawn

    Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as an adjuvant. … Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli.

    Synonyms: Lipoprotein outer surface a borrelia burgdorferi antigen
  9. Drug

    Trehalose-6-Phosphate

    go.drugbank.com/drugs/DB02430
    Experimental

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Trehalose-6-Phosphate
  10. Drug

    Trestolone

    go.drugbank.com/drugs/DB05830
    Investigational

    Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. … In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility.

    Synonyms: 17beta-Hydroxy-7alpha-methylestr-4-en-3-one, 7alpha-Methyl-3-oxo-4-estren-17beta-ol