Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities...
- Mechanism
- Curator reviewed
Trestolone is a potent inhibitor of the release of the luteinizing hormone (LH) and follicle stimulating hormone (FSH). As spermatogenesis requires both testosterone and FSH, it is impaired by the reduction in FSH caused by trestolone as well as the reduction in LH, and subsequent reduction in testosterone.
- Primary indication
- Investigated for use/treatment in contraception and male hormonal deficiencies/abnormalities.Curator reviewed
- Formula / weight
- C19H28O2 · 288.431 g/mol (avg)
- Also known as
- 19-Nor-methyltestosterone · 7alpha-Methylnandrolone · MENT
- Code names
- RU 27333
Resolves to
YSGQGNQWBLYHPE-CFUSNLFHSA-NSMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3C[C@@H](C)[C@@]21[H]What you can answer from here — as of July 03, 2026
Which drugs share a target with Trestolone, and which of those have an active Phase 3 trial?
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