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Displaying results 4261 - 4270 of 10000 in total
  1. Target

    Toll-like receptor 4

    go.drugbank.com/bio_entities/BE0002442
    TargetHumans

    Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634...

    Polypeptides: Toll-like receptor 4
  2. Target

    4-hydroxybenzoyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0002496
    TargetPseudomonas sp. (strain CBS-3)

    Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.

    Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseFunction: 4-hydroxybenzoyl-CoA thioesterase activity
  3. Target

    4-hydroxybenzoyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0002575
    TargetArthrobacter sp.

    Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseSynonyms: 4-HBA-CoA thioesterase
  4. Target

    Equilibrative nucleoside transporter 4

    go.drugbank.com/bio_entities/BE0004775
    TransporterTargetHumans

    Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubM...

    Polypeptides: Equilibrative nucleoside transporter 4Synonyms: Solute carrier family 29 member 4
  5. Target

    Penicillin-binding protein 4

    go.drugbank.com/bio_entities/BE0008485
    TargetStaphylococcus aureus

    Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

    Polypeptides: Penicillin-binding protein 4
  6. Target

    Proteinase-activated receptor 4

    go.drugbank.com/bio_entities/BE0008986
    TargetHumans

    Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109)

    Polypeptides: Proteinase-activated receptor 4Synonyms: PAR-4
  7. Target

    Bromodomain-containing protein 4

    go.drugbank.com/bio_entities/BE0010747
    TargetHumans

    Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMe...

    Polypeptides: Bromodomain-containing protein 4
  8. Target

    Krueppel-like factor 4

    go.drugbank.com/bio_entities/BE0011713
    TargetHumans

    Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription fac...

    Polypeptides: Krueppel-like factor 4
  9. Drug

    Pemetrexed

    go.drugbank.com/drugs/DB00642
    ApprovedInvestigational

    Its use in non-small cell lung cancer has also been investigated. Pemetrexed was first approved by the FDA in February 4, 2004.[A253907] … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: PRELUN® 500 MG, MARTXEL® 100 MG
  10. Target

    SEC14-like protein 4

    go.drugbank.com/bio_entities/BE0000076
    TargetTransporterHumans

    Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids

    Polypeptides: SEC14-like protein 4