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Tioguanine
go.drugbank.com/drugs/DB00352ApprovedInvestigationalAn antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Categories: Antineoplastic and Immunomodulating AgentsProducts: Lanvis Tablets 40mgInterferon alfacon-1
go.drugbank.com/drugs/DB00069ApprovedWithdrawnThe 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding … Prior to final purification, Interferon alfacon-1 is allowed to oxidize to its native state, and its final purity is achieved by sequential passage over a series of chromatography columns.
Categories: Interferon Type I, Amino Acids, Peptides, and ProteinsSynonyms: IFN-Con1, IFN Alfacon-1Denufosol
go.drugbank.com/drugs/DB04983InvestigationalDenufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial. … The drug was also evaluated in the treatment of retinal detachment and other diseases of the retina. Denufosol has not gained FDA approval, and clinical trials with this drug have ceased since 2011.
Categories: Nucleic Acids, Nucleotides, and NucleosidesNerandomilast
go.drugbank.com/drugs/DB18237ApprovedInvestigationalNerandomilast is a phosphodiesterase 4 (PDE4) inhibitor that preferentially inhibits the PDE4B subtype. It has one chiral center and is the R-stereoisomer. … [L54141] Nerandomilast exerts both anti-fibrotic and immunomodulatory effects as PDE4 inhibition elevates intracellular cAMP levels and reduces the expression of pro-fibrotic growth factors and inflammatory
Fluoride ion
go.drugbank.com/drugs/DB11257ApprovedInvestigationalFluoride ions are found in various minerals but are only present in trace amounts in water. … It also plays an essential physiological role, such as enhancing the resistance profile and strength of the surface tooth enamel.
Synonyms: Fluoride ionMixtures: Multi-Vitamin Fluoride and Iron Drops, ADDAMEL NInfluenza A virus A/Michigan/45/2015 X-275 (H1N1) antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB14458ApprovedVaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.
Mixtures: SKYCellflu Trivalent Solution for Injection in Prefilled Syringe 0.5ml, SKYCellflu Trivalent Solution for Injection in Prefilled Syringe 0.25mlDehydrocholic acid
go.drugbank.com/drugs/DB11622ApprovedThe use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada. … Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid [A33022]. It has been used for stimulation of biliary lipid secretion.
Categories: Bile Acids and Salts, Cholagogues and CholereticsProducts: Dycholium Tablet 300mgFluorometholone
go.drugbank.com/drugs/DB00324ApprovedInvestigationalA glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders.
Mixtures: FLUFORTE-N-LIQUIFILMCategories: Corticosteroids, Moderately Potent (Group II), fluorometholone and mydriaticsBatroxobin
go.drugbank.com/drugs/DB09005InvestigationalCurrently use is experimental but trials have been conducted which support certain clinical applications. Recombinant Batroxobin in relatively affordable and could be accessed by mass production. … The MW of batroxobin is approximately 43,000 g/mol-1, and it contains 231 amino acids. Batroxobin is inactivated by alpha2-macroglobulin, but not anti-thrombin compounds.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansMRK-003
go.drugbank.com/drugs/DB17015ExperimentalMRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. It is the preclinical analog of [MK-0752], a drug in clinical development.[A252682]
Categories: Gamma Secretase Inhibitors and Modulators