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Clonazepam
go.drugbank.com/drugs/DB01068ApprovedIllicitInvestigational[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history … Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one, 5-(2-chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-oneHyaluronidase
go.drugbank.com/drugs/DB14740ApprovedInvestigational[A199026] Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. … [A199047] Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338]
Products: POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION PARA ADMINISTRACIÓN OFTALMICA, HYLASE® DESSAU 150 IUCinnamon oil
go.drugbank.com/drugs/DB15986ApprovedInvestigationalCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsProducts: Nwk A-FV4-aminobutyrate aminotransferase GabT
go.drugbank.com/bio_entities/BE0001510TargetEscherichia coli (strain K12)Thereby functions in a GABA degradation pathway that allows some E.coli strains to utilize GABA as a nitrogen source for growth (PubMed:12446648). … Also catalyzes the conversion of 5-aminovalerate to glutarate semialdehyde, as part of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).
Polypeptides: 4-aminobutyrate aminotransferase GabTFunction: 4-aminobutyrate transaminase activityUDP-glucose 4-epimerase
go.drugbank.com/bio_entities/BE0001521TargetEnzymeHumansThe reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate.
Polypeptides: UDP-glucose 4-epimeraseSynonyms: UDP-GalNAc 4-epimerase, UDP-GlcNAc 4-epimerase4-hydroxy-tetrahydrodipicolinate reductase
go.drugbank.com/bio_entities/BE0001983TargetMycobacterium tuberculosisCatalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
Polypeptides: 4-hydroxy-tetrahydrodipicolinate reductaseFunction: 4-hydroxy-tetrahydrodipicolinate reductaseCyclin-dependent kinase 4
go.drugbank.com/bio_entities/BE0002216TargetHumansAlso phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.
Polypeptides: Cyclin-dependent kinase 4Synonyms: Cell division protein kinase 4Toll-like receptor 4
go.drugbank.com/bio_entities/BE0002442TargetHumansTransmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream … Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production
Polypeptides: Toll-like receptor 44-hydroxybenzoyl-CoA thioesterase
go.drugbank.com/bio_entities/BE0002496TargetPseudomonas sp. (strain CBS-3)Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.
Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseFunction: 4-hydroxybenzoyl-CoA thioesterase activity4-hydroxybenzoyl-CoA thioesterase
go.drugbank.com/bio_entities/BE0002575TargetArthrobacter sp.Polypeptides: 4-hydroxybenzoyl-CoA thioesteraseSynonyms: 4-HBA-CoA thioesterase