Cyclin-dependent kinase 4

BE0002216ProteinHumansCDK4

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. It is acted on by 29 drugs in DrugBank.

Gene name
CDK4
UniProtKB entry
P11802Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
303 residues · 33,730 Da
Also known as
2.7.11.22 · Cell division protein kinase 4 · PSK-J3

Resolves to

Protein
UniProtP11802UniProt nameCDK4_HUMAN
Gene
HGNCHGNC:1773NCBI Gene1019GenBank456427GeneCardsCDK4
Pharmacology
IUPHAR/GtoPdb1976KEGGhsa:1019
Structure
PDB2W96PDB2W99PDB2W9F
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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28Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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106+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 4, how selective are they, and which programs against it are still in active trials?

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