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Displaying results 4361 - 4370 of 10000 in total
  1. Target

    Krueppel-like factor 4

    go.drugbank.com/bio_entities/BE0011713
    TargetHumans

    Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription fac...

    Polypeptides: Krueppel-like factor 4
  2. Drug

    Clonazepam

    go.drugbank.com/drugs/DB01068
    ApprovedIllicitInvestigational

    [FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history … Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one, 5-(2-chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one
  3. Drug

    Flupentixol

    go.drugbank.com/drugs/DB00875
    ApprovedInvestigationalWithdrawn

    Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. … Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid.

    Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingProducts: FLUANXOL DEPOT 20MG/ML IM ENJ. SOLUSYON, 1 ADET, FLUANXOL 1 MG
  4. Target

    SEC14-like protein 4

    go.drugbank.com/bio_entities/BE0000076
    TargetTransporterHumans

    Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids

    Polypeptides: SEC14-like protein 4
  5. Target

    5-hydroxytryptamine receptor 4

    go.drugbank.com/bio_entities/BE0000084
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614

    Polypeptides: 5-hydroxytryptamine receptor 4Synonyms: 5-HT-4, Serotonin receptor 4
  6. Target

    4-hydroxy-tetrahydrodipicolinate synthase

    go.drugbank.com/bio_entities/BE0001460
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

    Polypeptides: 4-hydroxy-tetrahydrodipicolinate synthaseFunction: 4-hydroxy-tetrahydrodipicolinate synthase activity
  7. Target

    Transmembrane prolyl 4-hydroxylase

    go.drugbank.com/bio_entities/BE0002223
    TargetHumans

    Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. … May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex

    Polypeptides: Transmembrane prolyl 4-hydroxylaseSynonyms: HPH-4, HIF-prolyl hydroxylase 4
  8. Target

    UDP-glucose 4-epimerase

    go.drugbank.com/bio_entities/BE0002617
    TargetTrypanosoma brucei

    Polypeptides: UDP-glucose 4-epimeraseSynonyms: UDP-galactose 4-epimerase
  9. Target

    4-chlorobenzoyl CoA ligase

    go.drugbank.com/bio_entities/BE0003171
    TargetAlcaligenes sp. AL3007

    Polypeptides: 4-chlorobenzoyl CoA ligase
  10. Target

    ADP-ribosylation factor 4

    go.drugbank.com/bio_entities/BE0003277
    TargetHumans

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part...

    Polypeptides: ADP-ribosylation factor 4