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Large ribosomal subunit protein uL16
go.drugbank.com/bio_entities/BE0009104TargetHumansComponent of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788)
Synonyms: Laminin receptor homologMalacidin B
go.drugbank.com/drugs/DB14052ExperimentalMalacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. … Malacidin B, along with [DB14051], is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria [A33312].
Synonyms: Malacidin BSifalimumab
go.drugbank.com/drugs/DB12773InvestigationalSifalimumab is a fully human monoclonal antibody targeting interferon-alpha. … Sifalimumab may suppress the abnormal immune activity associated with lupus by binding to multiple interferon-alpha subtypes seen in the serum of lupus patients.
Velusetrag
go.drugbank.com/drugs/DB12702InvestigationalIt is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance. … Velusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease.
Interferon Kappa
go.drugbank.com/drugs/DB15749ExperimentalThis gene encoding for this interferon is expressed in human epidermal keratinocytes. … a 27-amino acid signal peptide conserved in type I interferons.
Synonyms: IFN‐κEvofosfamide
go.drugbank.com/drugs/DB06091InvestigationalTH-302 has been shown, in preclinical studies, to be both efficacious and well tolerated. … TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs such as ifosfamide, cyclophosphamide, and glufosfamide.
Synonyms: (1-methyl-2-nitro-1H-imidazol-5-YL)methyl N,N'-bis(2-bromoethyl)diamidophosphate, (1-methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphateCategories: Heterocyclic Compounds, 1-RingBanoxantrone
go.drugbank.com/drugs/DB04975InvestigationalBanoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic to, hypoxic cells in tumours. … It has been shown to work synergistically with fractionated radiation to significantly delay growth of tumours compared to administration of either banoxantrone or radiation alone.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesPiclamilast
go.drugbank.com/drugs/DB01791ExperimentalIt has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma. … Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects.
Synonyms: 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamideCategories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 4 InhibitorsMalacidin A
go.drugbank.com/drugs/DB14051ExperimentalMalacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. … Malacidin A, along with [DB14052], is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria [A33312].
Synonyms: Malacidin AGremlin-1
go.drugbank.com/bio_entities/BE0011799TargetHumansCytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 ...
Synonyms: Cell proliferation-inducing gene 2 protein