Sifalimumab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sifalimumab
DrugBank Accession Number
DB12773
Background

Sifalimumab is a fully human monoclonal antibody targeting interferon-alpha. The levels of interferon-alpha are elevated in many patients with active systemic lupus erythematosus (SLE, or lupus) and other autoimmune disorders, and may be associated with disease activity. Sifalimumab may suppress the abnormal immune activity associated with lupus by binding to multiple interferon-alpha subtypes seen in the serum of lupus patients.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Sifalimumab
External IDs
  • MEDI-545

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UInterferon alpha-2Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Sifalimumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Sifalimumab.
AducanumabThe risk or severity of adverse effects can be increased when Aducanumab is combined with Sifalimumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Sifalimumab.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Sifalimumab.
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
XOY1YA7RMC
CAS number
1006877-41-3

References

General References
Not Available
PubChem Substance
347911377
Wikipedia
Sifalimumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentLupus / Systemic Lupus Erythematosus1
2CompletedTreatmentSystemic Lupus Erythematosus3
1CompletedTreatmentChronic Plaque Psoriasis1
1CompletedTreatmentDermatomyositis or polymyositis1
1CompletedTreatmentLupus2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Type i interferon receptor binding
Specific Function
Produced by macrophages, IFN-alpha have antiviral activities.
Gene Name
IFNA2
Uniprot ID
P01563
Uniprot Name
Interferon alpha-2
Molecular Weight
21549.765 Da

Drug created at October 21, 2016 00:10 / Updated at February 21, 2021 18:53