Search
Difluprednate
go.drugbank.com/drugs/DB06781ApprovedInvestigationalIt is indicated for treatment of endogenous anterior uveiti. … Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBetamethasone phosphate
go.drugbank.com/drugs/DB14669ApprovedVet approvedBetamethasone phosphate is a prodrug that is rapidly hydrolyzed, providing rapidly accessible betamethasone to agonize glucocorticoid receptors. Betamethasone provides greater anti-inflammatory activity than prednisolone with less sodium...
Categories: P-glycoprotein inducers, Cytochrome P-450 CYP3A InducersTelcagepant
go.drugbank.com/drugs/DB12228InvestigationalIt is an antagonist of the receptor for calcitonin gene-related peptide (CGRP), a primary neuropeptide involved in the pathophysiology of migraine. … Telcagepant has been investigated for the treatment of Migraine.
T611
go.drugbank.com/drugs/DB06391ExperimentalT611 is an investigational oral anti-cytomegalovirus (CMV) drug candidate.
Atenolol Action Pathway
smpdb.ca/view/SMP0000298Drug actionAtenolol, trade name Tenormin, is a beta blocker prescribed to treat hypertension. Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity. Binding of atenolol...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Bisoprolol Action Pathway
smpdb.ca/view/SMP0000300Drug actionBisoprolol (also known as Zebeta) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors. Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart ...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Metoprolol Action Pathway
smpdb.ca/view/SMP0000302Drug actionMetoprolol (also known as Lopressor) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Metoprolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of o...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Pindolol Action Pathway
smpdb.ca/view/SMP0000306Drug actionPindolol (also known as Visken) a beta blocker (non-selective) that block beta-1 adrenergic receptor in heart. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Procainamide (Antiarrhythmic) Action Pathway
smpdb.ca/view/SMP0000324Drug actionThis drug may be administered intravenously to treat supraventricular and ventricular arrhythmias. It is better tolerated intravenously than quinidine.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Fosphenytoin (Antiarrhythmic) Action Pathway
smpdb.ca/view/SMP0000326Drug actionThis pathway illustrates the fosphenytoin targets involved in antiarrhythmic therapy. Contractile activity of cardiac myocytes is elicited via action potentials mediated by a number of ion channel proteins. During rest, or diastole, cell...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2