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Ezetimibe
go.drugbank.com/drugs/DB00973ApprovedInvestigationalC1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids. … [A33313] In genetically NPC1L1-deficient mice, a 70% reduction in intestinal cholesterol absorption was seen, and these mice were insensitive to ezetimibe treatment - it was determined based on these findings
Mixtures: TIAZOMET ® A 40/10 TABLETAS, LIPIVAN E ® 10 MG / 10 MGCategories: Heterocyclic Compounds, 1-Ring, Hypolipidemic Agents Indicated for HyperlipidemiaInterleukin-10
go.drugbank.com/bio_entities/BE0002484TargetHumansMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...
Polypeptides: Interleukin-10Synonyms: IL-10Aquaporin-10
go.drugbank.com/bio_entities/BE0018706TransporterHumansAquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...
Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10Ocrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalPrimary progressive multiple sclerosis (PPMS) accounts for 10-15% of the overall population of patients with MS, and leads to the gradual worsening of neurologic disability from symptom onset, often without … Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS).
Products: OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADETPipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnAmong the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. … However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients.
Products: PIPORTIL ® L-4SOLUCION INYECTABLE AL 2.5% (100 MG)., TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/MLChlorpheniramine
go.drugbank.com/drugs/DB01114ApprovedInvestigationalA histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications.
Synonyms: 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane, 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamineMixtures: Medicament Pour Le Rhume, Nuit, A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 20 ADETTranexamic acid
go.drugbank.com/drugs/DB00302ApprovedInvestigationalIt possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. … Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding.
Synonyms: trans-4-aminomethylcyclohexane-1-carboxylic acidProducts: TRANSAMINE 100 MG/ML IV ENJ COZELTI, 10 ADET, Tranexamsäure Kabi 10 mg/ml InfusionslösungNitroglycerin
go.drugbank.com/drugs/DB00727ApprovedInvestigational[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins. … Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.
Mixtures: NITROGLICERINA 0.1 MG/ML EN DEXTROSA 5% SOLUCION INYECTABLE, .-400mcg/mlCategories: Compounds used in a research, industrial, or household setting, Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseDyphylline
go.drugbank.com/drugs/DB00651ApprovedWithdrawnDyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Mixtures: ESPEKTAN A ŞURUP, 100 ML, ESPEKTAN ŞURUP, 100 MLCategories: Drugs for Obstructive Airway DiseasesMethylprednisolone
go.drugbank.com/drugs/DB00959ApprovedInvestigationalVet approved[L10785] In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with long-term immunosuppression. … Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s.
Synonyms: 1-dehydro-6α-methylhydrocortisone, delta(1)-6alpha-MethylhydrocortisoneMixtures: Physicians EZ Use M-pred, Physicians EZ Use M-pred