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Lamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalA reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. … It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Mixtures: N/A, N/ACategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingL-lactate dehydrogenase A-like 6A
go.drugbank.com/bio_entities/BE0000297TargetHumansCatalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441).
Polypeptides: L-lactate dehydrogenase A-like 6AD-alanine--D-alanine ligase A
go.drugbank.com/bio_entities/BE0000733TargetEscherichia coli (strain K12)Cell wall formation.
Polypeptides: D-alanine--D-alanine ligase ASynonyms: D-Ala-D-Ala ligase A, D-alanylalanine synthetase APeptidyl-prolyl cis-trans isomerase A
go.drugbank.com/bio_entities/BE0001014TargetHumansInhibits replication of influenza A virus (IAV) (PubMed:19207730). … Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775
Polypeptides: Peptidyl-prolyl cis-trans isomerase ASynonyms: PPIase A, Rotamase ARibosomal small subunit pseudouridine synthase A
go.drugbank.com/bio_entities/BE0001276TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.
Polypeptides: Ribosomal small subunit pseudouridine synthase ASynonyms: rRNA-uridine isomerase A, rRNA pseudouridylate synthase AMethane monooxygenase component A alpha chain
go.drugbank.com/bio_entities/BE0003331TargetEnzymeMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
Polypeptides: Methane monooxygenase component A alpha chainDNA polymerase epsilon catalytic subunit A
go.drugbank.com/bio_entities/BE0003614TargetHumansAlong with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)
Polypeptides: DNA polymerase epsilon catalytic subunit ASynonyms: DNA polymerase II subunit ATrimipramine
go.drugbank.com/drugs/DB00726ApprovedInvestigationalTricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexSynonyms: 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine, 5-(γ-dimethylamino-β-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepinePutative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
go.drugbank.com/bio_entities/BE0023607EnzymeHumansCatalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation (By similarity
Polypeptides: Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylaseSynonyms: Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseMethylmalonic aciduria type A protein, mitochondrial
go.drugbank.com/bio_entities/BE0000320TargetHumansPlays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). … Functions as a G protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:20876572, PubMed:28497574).
Polypeptides: Methylmalonic aciduria type A protein, mitochondrial