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Ifosfamide
go.drugbank.com/drugs/DB01181ApprovedInvestigationalIfosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Categories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexSynonyms: 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxideAcyclovir
go.drugbank.com/drugs/DB00787ApprovedInvestigational[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. … Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis.
Mixtures: Activir Duo 50 mg/g + 10 mg/g Creme, HERPAZON % 5 + % 1 KREM, 5 GRAMCategories: MATE 1 Substrates, MATE 2 SubstratesLoratadine
go.drugbank.com/drugs/DB00455ApprovedInvestigationalLoratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. … [A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
Mixtures: Clarinase 5 mg/ 120 mg Retardtabletten, LORATADINA+ PSEUDOEFEDRINA0.5 MG + 6 MG/ML SOLUCION PEDIATRICACategories: P-glycoprotein inhibitors, P-glycoprotein substratesL-lactate dehydrogenase A-like 6A
go.drugbank.com/bio_entities/BE0000297TargetHumansCatalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441).
Polypeptides: L-lactate dehydrogenase A-like 6AD-alanine--D-alanine ligase A
go.drugbank.com/bio_entities/BE0000733TargetEscherichia coli (strain K12)Cell wall formation.
Polypeptides: D-alanine--D-alanine ligase ASynonyms: D-Ala-D-Ala ligase A, D-alanylalanine synthetase APeptidyl-prolyl cis-trans isomerase A
go.drugbank.com/bio_entities/BE0001014TargetHumansInhibits replication of influenza A virus (IAV) (PubMed:19207730). … Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775
Polypeptides: Peptidyl-prolyl cis-trans isomerase ASynonyms: PPIase A, Rotamase ARibosomal small subunit pseudouridine synthase A
go.drugbank.com/bio_entities/BE0001276TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.
Polypeptides: Ribosomal small subunit pseudouridine synthase ASynonyms: rRNA-uridine isomerase A, rRNA pseudouridylate synthase AMethane monooxygenase component A alpha chain
go.drugbank.com/bio_entities/BE0003331TargetEnzymeMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
Polypeptides: Methane monooxygenase component A alpha chainDNA polymerase epsilon catalytic subunit A
go.drugbank.com/bio_entities/BE0003614TargetHumansAlong with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)
Polypeptides: DNA polymerase epsilon catalytic subunit ASynonyms: DNA polymerase II subunit APutative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
go.drugbank.com/bio_entities/BE0023607EnzymeHumansCatalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation (By similarity
Polypeptides: Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylaseSynonyms: Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase