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Displaying results 4441 - 4450 of 10000 in total
  1. Target

    Sphingolipid delta(4)-desaturase DES1

    go.drugbank.com/bio_entities/BE0011584
    TargetHumans

    Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338).

    Polypeptides: Sphingolipid delta(4)-desaturase DES1
  2. Target

    Transcriptional enhancer factor TEF-4

    go.drugbank.com/bio_entities/BE0014575
    TargetHumans

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a ki...

    Polypeptides: Transcriptional enhancer factor TEF-4
  3. Drug

    Talc

    go.drugbank.com/drugs/DB09511
    ApprovedInvestigational

    It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders. … Talc is a mineral composed primarily of magnesium, silicon and oxygen.

    Mixtures: OHUI Sun Science Sun Block EX plus BeigeCategories: Compounds used in a research, industrial, or household setting
  4. Drug

    Pertuzumab

    go.drugbank.com/drugs/DB06366
    ApprovedInvestigational

    Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). … Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.

    Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: Receptor, ErbB-2, antagonists & inhibitors, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  5. Drug

    Iodixanol

    go.drugbank.com/drugs/DB01249
    Approved

    Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the

    Mixtures: BL-C KitCategories: Compounds used in a research, industrial, or household setting, X-Ray Contrast Activity
  6. Indication

    Stage IV Primary Peritoneal Cancer

    go.drugbank.com/conditions/DBCOND0030573
    Drugs: Bevacizumab
    Synonyms: Primary, stage 4 Peritoneal Cancer, Stage 4 Primary Peritoneal Cancer
  7. Drug

    Dapoxetine

    go.drugbank.com/drugs/DB04884
    Investigational

    In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. … Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December 2004.

    Mixtures: TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET, DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  8. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits … Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the

    Mixtures: Diliban 75 mg/650 mg Tabletten, Diliban 37,5 mg/325 mg TablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  9. Drug

    Bos taurus skin

    go.drugbank.com/drugs/DB10406
    Approved

    Bos taurus skin or pelt is used in allergenic testing.

    Categories: Non-Standardized Animal Skin Allergenic ExtractSynonyms: Bos taurus skin, domestic cow skin extract
  10. Drug

    Equus caballus skin

    go.drugbank.com/drugs/DB10410
    Approved

    Equus caballus skin allergenic extract is used in allergenic testing.

    Categories: Non-Standardized Animal Skin Allergenic ExtractSynonyms: Equine skin, Horse skin