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Atropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedAtropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Mixtures: SP-ARNOX SYRUP, Se-donna Pb HyosCategories: P-glycoprotein substratesValdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesProducts: PARALGEN ® 40, PARALGEN ® 20 TABLETASNizatidine
go.drugbank.com/drugs/DB00585ApprovedA histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamineEthosuximide
go.drugbank.com/drugs/DB00593ApprovedInvestigationalAn anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Synonyms: 2-ethyl-2-methylsuccinimide, (±)-2-ethyl-2-methylsuccinimideCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingEthionamide
go.drugbank.com/drugs/DB00609ApprovedInvestigationalWithdrawnA second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-ethyl-4-thiopyridylamide, 2-ethylthioisonicotinamidePrednisone
go.drugbank.com/drugs/DB00635ApprovedInvestigationalVet approvedA synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.
Categories: CHOP-R chemotherapy regimen, P-glycoprotein inducersSynonyms: 1, 2-DehydrocortisoneDyphylline
go.drugbank.com/drugs/DB00651ApprovedWithdrawnDyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Mixtures: Dy G, Dilex-G 400Categories: Heterocyclic Compounds, 2-RingMetaxalone
go.drugbank.com/drugs/DB00660ApprovedInvestigationalMetaxalone is associated with few side effects and is available as a 800 mg scored tablet. … It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Heterocyclic Compounds, 1-RingPentosan polysulfate
go.drugbank.com/drugs/DB00686ApprovedInvestigationalPentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.
Synonyms: (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULFATE, (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULPHATEInternational brands: Tavan-SPLamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalIt is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). … A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring.
Mixtures: N/A, N/ACategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-Ring