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Levoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalHowever, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). … In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys.
Synonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acidFusidic acid
go.drugbank.com/drugs/DB02703ApprovedInvestigationalAn antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. … It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.
Gatifloxacin
go.drugbank.com/drugs/DB01044ApprovedInvestigationalWithdrawnIt works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. … It is also available as eye drops under the brand name Zymar® marketed by Allergan.
Mixtures: Pred-Gati-Brom, Pred-Gati-BromAmmonium chloride
go.drugbank.com/drugs/DB06767ApprovedInvestigationalVet approvedAmmonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Mixtures: NO- TOC JARABE, PULBRONC NF ADULTOSPramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalThe prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 [A176861]. … It was first approved by the FDA in 1997 [L5882].
Synonyms: (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamineProducts: Nu-pramipexole, Nb-pramipexolePepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnStudies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve. … Soon afterward, it was shown that these protein nutrients were cleaved by pepsin to products called _peptones_ [A32603].
Mixtures: Glutamic Acid Hydrochloride Nu LifeThrombin alfa
go.drugbank.com/drugs/DB11572ApprovedThrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically converted to a two-chain active form (using a protein derived from snakes) and is purified by a chromatographic … The thrombin alfa product ultimate comes from recombinant human prethrombin-1 [L2079].
Foreskin fibroblast (neonatal)
go.drugbank.com/drugs/DB10770ApprovedForeskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types [A32660]. … Dermagraft was introduced in the United Kingdom in October 1997, and several other European countries, as well as New Zealand and Australia.
Peanut oil
go.drugbank.com/drugs/DB13964ApprovedWithdrawnThe kernels are consumed roasted but a large percentage is used for the production of vegetable oil. … The peanut oil represents about 45-52% of the kernel content and it is mainly formed from monounsaturated fat from which the major component is [DB04224].
Sarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationalSarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 … scarring resulting from cases of severe acne [L4814].