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Displaying results 441 - 450 of 2828 in total
  1. Drug

    Hydralazine

    go.drugbank.com/drugs/DB01275
    ApprovedInvestigational

    Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hyperte...

    Mixtures: Ser-Ap-Es, Ser-AP-ES Tab
  2. Drug

    Selinexor

    go.drugbank.com/drugs/DB11942
    ApprovedInvestigational

    Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. … [L7117,L7120,L10145] This condition is typically treated with high dose [bortezomib] and [dexamethasone] chemotherapy followed by an autologous stem-cell transplant.

  3. Target

    Solute carrier family 2, facilitated glucose transporter member 4

    go.drugbank.com/bio_entities/BE0000893
    TransporterTargetHumans

    Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. … Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 4Synonyms: Glucose transporter type 4, insulin-responsive
  4. Target

    Solute carrier family 2, facilitated glucose transporter member 3

    go.drugbank.com/bio_entities/BE0004707
    TransporterTargetHumans

    Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). … Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity)

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 3Synonyms: Glucose transporter type 3, brain
  5. Target

    Solute carrier family 2, facilitated glucose transporter member 7

    go.drugbank.com/bio_entities/BE0005218
    TransporterHumans

    Probable sugar transporter (PubMed:28083649). … Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637)

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 7Synonyms: Glucose transporter type 7
  6. Target

    Solute carrier family 2, facilitated glucose transporter member 8

    go.drugbank.com/bio_entities/BE0005219
    TransporterHumans

    Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). … Also able to mediate the transport of dehydroascorbate

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 8Synonyms: Glucose transporter type 8, Glucose transporter type X1
  7. Target

    Sodium-dependent neutral amino acid transporter B(0)AT1

    go.drugbank.com/bio_entities/BE0015577
    TransporterTargetHumans

    Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:18424768, PubMed:19185582) … Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed

    Polypeptides: Sodium-dependent neutral amino acid transporter B(0)AT1Synonyms: System B(0) neutral amino acid transporter AT1
  8. Target

    Solute carrier family 2, facilitated glucose transporter member 14

    go.drugbank.com/bio_entities/BE0017439
    TransporterHumans

    Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane

    Polypeptides: Solute carrier family 2, facilitated glucose transporter member 14Synonyms: Glucose transporter type 14
  9. Drug

    Remlarsen

    go.drugbank.com/drugs/DB19131
    Investigational

    Remlarsen is under investigation in clinical trial NCT03601052 (Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids).

    Synonyms: -cholest-5-en-3-yloxy)hexyl)oxy)-2-hydroxypropyl hydrogen phosphate), complex with rna ((2'-deoxy-2'-fluoro)u-a-g-(2'-deoxy-2'-fluoro)c-a-(2'-deoxy-2'-fluoro)c-(2'-de
  10. Drug

    Alpha-1-proteinase inhibitor

    go.drugbank.com/drugs/DB00058
    ApprovedInvestigational

    Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

    Synonyms: Wap four-disulfide core domain protein 4