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Displaying results 4531 - 4540 of 10000 in total

Drug
GC-376 free acid
go.drugbank.com/drugs/DB15796
Experimental
A prodrug of [GC-373], GC-376 has recently been used to test inhibition of SARS-Cov-2 Mpro _in vitro_, and results show potent inhibition of this target[A219036]. … GC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells
Categories: Heterocyclic Compounds, 1-Ring
Drug
Cethromycin
go.drugbank.com/drugs/DB06419
Investigational
[L13988] It has also been investigated, by itself or together with [zoliflodacin], for the treatment of gonorrhea,[A203432, A203495] and was recently suggested as a possible treatment for liver-stage _ … Cethromycin is a 3-keto (ketolide) derivative of erythromycin A with an 11,12-carbamate group and an O-6-linked aromatic ring system.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
Drug
Ligelizumab
go.drugbank.com/drugs/DB11856
Investigational
Ligelizumab is a humanized IgG1k monoclonal antibody targeted against immunoglobulin E (IgE). … autoantibodies against IgE receptors, and sometimes against IgE itself, are thought to exist in 30-40% of patients,[A242362,A242367] and the efficacy anti-IgE antibody therapy in the treatment of CSU has been
Drug
Picolinic acid
go.drugbank.com/drugs/DB05483
Experimental
Picolinic acid has been shown to be an anti-viral in vitro and in vivo, and sometimes works in conjunction with other cytokines such as interferon gamma to affect immune responses. … PCL-016 plays a key role in zinc transport.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 2-Carboxypyridine
Target
L-selectin
go.drugbank.com/bio_entities/BE0010361
TargetHumans
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial ven...
Synonyms: Lymph node homing receptor
Target
Calcium-activated potassium channel subunit beta-4
go.drugbank.com/bio_entities/BE0004424
TargetHumans
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium se...
Synonyms: Charybdotoxin receptor subunit beta-4
Drug
Fucoxanthin
go.drugbank.com/drugs/DB15462
Investigational
Fucoxanthin isis a marine carotenoid mainly found in brown algae, giving them a brown or olive-green color. … A clinical trial of fucoxanthin against non-alcoholic fatty liver disease is ongoing.
Drug
Insulin degludec
go.drugbank.com/drugs/DB09564
ApprovedInvestigational
damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. … [A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed later in the course of T2D, after several oral medications such as [DB00331], [DB01120], or [DB01261] have been tried, when sufficient
Mixtures: RyzodegÂ® FlexTouchÂ® 100 U/ml Solution for Injection, RYZODEG PENFİLL 100 U/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KARTUŞ, 5 ADETCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers
Target
Calcium-activated potassium channel subunit beta-2
go.drugbank.com/bio_entities/BE0003196
TargetHumans
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers ra...
Synonyms: Charybdotoxin receptor subunit beta-2
Drug
Basic Fibroblast Growth Factor
go.drugbank.com/drugs/DB14131
Investigational
Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. … Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis.
Categories: Fibroblast Growth Factor 2, antagonists & inhibitorsSynonyms: FGF 2, FGF-2