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Aripiprazole
go.drugbank.com/drugs/DB01238ApprovedInvestigational[L45859] It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. … Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's.
Categories: Dopamine D2 Receptor Antagonists, P-glycoprotein inhibitorsProducts: DM-ARBendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalThrough this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: BEN SPAL-P® 25, BENDAMUSTINA DR. REDDY'SPropofol
go.drugbank.com/drugs/DB00818ApprovedInvestigationalVet approvedPropofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia.
Categories: P-glycoprotein inducers, Cytochrome P-450 SubstratesProducts: PROPOFOL-PF %1 200 MG/20 ML I.V. ENJEKSİYONLUK/İNFÜZYONLUK EMÜLSİYON, 5 ADETSerplulimab
go.drugbank.com/drugs/DB17451ApprovedInvestigationalSerplulimab is a humanized monoclonal IgG4 antibody that acts as an immune checkpoint inhibitor by targeting the programmed cell death-1 (PD-1) receptor. … Most recently, it was approved in the EU in February 2025 for the treatment of extensive-stage small cell lung cancer.[L52968,L52953]
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsPembrolizumab
go.drugbank.com/drugs/DB09037ApprovedInvestigationalPembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors. … It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsTriamcinolone
go.drugbank.com/drugs/DB00620ApprovedInvestigationalVet approved[L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L8264] or first line as a topical treatment of corticosteroid responsive dermatoses.
Mixtures: KRIM PI KANG SHUANG, P-Care K40Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersToripalimab
go.drugbank.com/drugs/DB15043ApprovedInvestigationalOne mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1)[A261506] - the binding of PD-L1 (and PD-L2) to its target receptor (PD-1) results in the inhibition … The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsLevonorgestrel
go.drugbank.com/drugs/DB00367ApprovedInvestigational[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: d(-)-NorgestrelDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalDostarlimab is an IgG<sub>4</sub> humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). … [L33320] PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsAtropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedAtropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods.
Mixtures: PB Hyos, Re-PB HyosCategories: P-glycoprotein substrates