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Telithromycin
go.drugbank.com/drugs/DB00976ApprovedTelithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedLomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsCytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalA pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specif...
International brands: Cytosar-UCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDoxorubicin
go.drugbank.com/drugs/DB00997ApprovedInvestigationalDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxor...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: DOXOLEM RU, DOXORUBICIN AU 2MG/ML 10MGGuanfacine
go.drugbank.com/drugs/DB01018ApprovedInvestigationalGuanfacine, or BS 100-141, is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first descr...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Ag-guanfacine XRKetoconazole
go.drugbank.com/drugs/DB01026ApprovedInvestigationalKetoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increa...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMemantine
go.drugbank.com/drugs/DB01043ApprovedInvestigationalInitially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD).
Categories: N-methyl-D-aspartate Receptor Antagonist, Cytochrome P-450 CYP2A6 InhibitorsFluocinonide
go.drugbank.com/drugs/DB01047ApprovedInvestigationalA topical glucocorticoid used in the treatment of eczema.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersNitrendipine
go.drugbank.com/drugs/DB01054ApprovedWithdrawnNitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natri...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesOxybutynin
go.drugbank.com/drugs/DB01062ApprovedInvestigationalOveractive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors