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Displaying results 4661 - 4670 of 8974 in total
  1. Drug

    Trichloroacetate

    go.drugbank.com/drugs/DB11152
    ApprovedInvestigational

    Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. … Trichloroacetate is also found in cosmetic treatments and topical formulations as a cauterant, which removes condyloma or warts on the skin.

    Categories: Compounds used in a research, industrial, or household setting
  2. Drug

    LErafAON

    go.drugbank.com/drugs/DB04973
    Investigational

    NeoPharm is developing liposome-encapsulated, c-Raf antisense oligodeoxynucleotides (LErafAON) for the potential treatment of various solid tumors, including those that have become resistant to radiation … or chemotherapy.

  3. Drug

    Aluminum oxide

    go.drugbank.com/drugs/DB11342
    ApprovedWithdrawn

    It is considered an indirect additive used in food contact substances by the FDA.

    Categories: Anti-Acne Preparations for Topical Use
  4. Drug

    Curcuma aromatica root oil

    go.drugbank.com/drugs/DB11301
    Approved

    Curcuma aromatica root oil is obtained from the roots of *Curcuma aromatica*, or more commonly called wild tumeric, via steamed distillation. *Curcuma aromatica* belongs to the family Zingiberaceae. … Curcuma aromatica root oil is also suggested to have antibacterial activity.

  5. Drug

    Ormeloxifene

    go.drugbank.com/drugs/DB13310
    Experimental

    [A251475] The use of levormeloxifene for the treatment of reduced bone turnover and the prevention of atherosclerosis has been evaluated; however, drug development was discontinued due to adverse events … [A251450,A251465] The use of ormeloxifene for the treatment of perimenopausal bleeding and the management of menorrhagia has also been investigated.

    Categories: Hormonal Contraceptives for Systemic Use
  6. Target

    Signal recognition particle protein

    go.drugbank.com/bio_entities/BE0001792
    TargetThermus aquaticus

    Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. … The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

    Synonyms: Fifty-four homolog
  7. Drug

    Imexon

    go.drugbank.com/drugs/DB05003
    Investigational

    Imexon is currently being studied for the treatment of pancreatic, lung, breast, prostate, melanoma, and multiple myeloma cancers. It belongs to the family of drugs called cyanoaziridine derivatives. … Imexon is a thiol-binding small molecule which induces mitochondrial oxidation, a loss of membrane potential and cytochrome C, leading to apoptosis.

  8. Drug

    Acadesine

    go.drugbank.com/drugs/DB04944
    Investigational

    It is being developed jointly by PeriCor and Schering-Plough. Acadesine has been granted Orphan Drug Designation for B-CLL in the EU. … Acadesine (AICA-riboside) is a purine nucleoside analog with anti-ischemic properties that is currently being studied (Phase 3) for the prevention of adverse cardiovascular outcomes in patients undergoing

  9. Drug

    Tenofovir

    go.drugbank.com/drugs/DB14126
    Investigational

    to obtain oral bioavailability. … [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog.

  10. Target

    Sulfotransferase 2A1

    go.drugbank.com/bio_entities/BE0000886
    TargetEnzymeHumans

    Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:14573603, PubMed:18042734

    Synonyms: Bile salt sulfotransferase